Accelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85767
Title:
Accelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant.
Authors:
Robertson, J D; Testa, Nydia G; Russell, N H; Jackson, G; Parker, A N; Milligan, D W; Stainer, C; Chakrabarti, S; Dougal, Mark; Chopra, Rajesh
Abstract:
Telomere shortening has been documented in the blood cells of recipients of allogeneic bone marrow transplants compared with their donors. Allogeneic peripheral blood progenitor cells (PBPCs) have been increasingly used as an alternative to bone marrow. Their advantages include earlier engraftment and immune reconstitution following transplantation. We have measured telomere length of neutrophils and T cells in fully engrafted recipients of allogeneic bone marrow (n = 19) and allogeneic PBPC (n = 17) and also measured sequential telomere length in four patients after transplantation. Overall, significant telomere shortening occurred in recipients in neutrophils (0.3 kb, P < 0.001) and T cells (0.2 kb, P = 0.045). The data demonstrate that first, the degree of shortening was the same for BM and PBPC transplants and was not related to the time taken to engraft neutrophils and platelets and second, telomere shortening occurs in the first year post transplant without further shortening during the period of observation. These data suggest that the superiority of engraftment seen in PBPC transplants is independent of telomere shortening and other mechanisms such as homing or seeding may be more important.
Affiliation:
CRC Laboratory of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Accelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant. 2001, 27 (12):1283-6 Bone Marrow Transplant.
Journal:
Bone Marrow Transplantation
Issue Date:
Jun-2001
URI:
http://hdl.handle.net/10541/85767
DOI:
10.1038/sj.bmt.1703069
PubMed ID:
11548846
Type:
Article
Language:
en
ISSN:
0268-3369
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorRobertson, J Den
dc.contributor.authorTesta, Nydia Gen
dc.contributor.authorRussell, N Hen
dc.contributor.authorJackson, Gen
dc.contributor.authorParker, A Nen
dc.contributor.authorMilligan, D Wen
dc.contributor.authorStainer, Cen
dc.contributor.authorChakrabarti, Sen
dc.contributor.authorDougal, Marken
dc.contributor.authorChopra, Rajeshen
dc.date.accessioned2009-11-10T10:43:34Z-
dc.date.available2009-11-10T10:43:34Z-
dc.date.issued2001-06-
dc.identifier.citationAccelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant. 2001, 27 (12):1283-6 Bone Marrow Transplant.en
dc.identifier.issn0268-3369-
dc.identifier.pmid11548846-
dc.identifier.doi10.1038/sj.bmt.1703069-
dc.identifier.urihttp://hdl.handle.net/10541/85767-
dc.description.abstractTelomere shortening has been documented in the blood cells of recipients of allogeneic bone marrow transplants compared with their donors. Allogeneic peripheral blood progenitor cells (PBPCs) have been increasingly used as an alternative to bone marrow. Their advantages include earlier engraftment and immune reconstitution following transplantation. We have measured telomere length of neutrophils and T cells in fully engrafted recipients of allogeneic bone marrow (n = 19) and allogeneic PBPC (n = 17) and also measured sequential telomere length in four patients after transplantation. Overall, significant telomere shortening occurred in recipients in neutrophils (0.3 kb, P < 0.001) and T cells (0.2 kb, P = 0.045). The data demonstrate that first, the degree of shortening was the same for BM and PBPC transplants and was not related to the time taken to engraft neutrophils and platelets and second, telomere shortening occurs in the first year post transplant without further shortening during the period of observation. These data suggest that the superiority of engraftment seen in PBPC transplants is independent of telomere shortening and other mechanisms such as homing or seeding may be more important.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBlood Cells-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshGraft Survival-
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshNeutrophils-
dc.subject.meshT-Lymphocytes-
dc.subject.meshTelomere-
dc.subject.meshTime Factors-
dc.subject.meshTransplantation, Homologous-
dc.titleAccelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant.en
dc.typeArticleen
dc.contributor.departmentCRC Laboratory of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBone Marrow Transplantationen

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