2.50
Hdl Handle:
http://hdl.handle.net/10541/85763
Title:
The role of human papillomavirus vaccines in cervical neoplasia.
Authors:
Stern, Peter L; Faulkner, Rebecca L; Veranes, Emma C; Davidson, Emma J
Abstract:
Cervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.
Affiliation:
Immunology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.
Citation:
The role of human papillomavirus vaccines in cervical neoplasia. 2001, 15 (5):783-99 Best Pract Res Clin Obstet Gynaecol
Journal:
Best Practice & Research. Clinical Obstetrics & Gynaecology
Issue Date:
Oct-2001
URI:
http://hdl.handle.net/10541/85763
DOI:
10.1053/beog.2001.0220
PubMed ID:
11563873
Type:
Article
Language:
en
ISSN:
1521-6934
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorStern, Peter Len
dc.contributor.authorFaulkner, Rebecca Len
dc.contributor.authorVeranes, Emma Cen
dc.contributor.authorDavidson, Emma Jen
dc.date.accessioned2009-11-10T10:33:45Z-
dc.date.available2009-11-10T10:33:45Z-
dc.date.issued2001-10-
dc.identifier.citationThe role of human papillomavirus vaccines in cervical neoplasia. 2001, 15 (5):783-99 Best Pract Res Clin Obstet Gynaecolen
dc.identifier.issn1521-6934-
dc.identifier.pmid11563873-
dc.identifier.doi10.1053/beog.2001.0220-
dc.identifier.urihttp://hdl.handle.net/10541/85763-
dc.description.abstractCervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.en
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subjectUterine Cervical Canceren
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshPapillomaviridae-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshPapillomavirus Vaccines-
dc.subject.meshTumor Virus Infections-
dc.subject.meshUterine Cervical Neoplasms-
dc.subject.meshViral Vaccines-
dc.titleThe role of human papillomavirus vaccines in cervical neoplasia.en
dc.typeArticleen
dc.contributor.departmentImmunology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.en
dc.identifier.journalBest Practice & Research. Clinical Obstetrics & Gynaecologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.