HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85758
Title:
HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.
Authors:
Sánchez-Díaz, Alberto; Blanco, Miguel A; Jones, Nic; Moreno, Sergio
Abstract:
The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates CdclO-dependent transcription at G1/S and allows growth of cdc10-129, resldelta and rep2delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.
Affiliation:
Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genética, CSIC/Universidad de Salamanca, Spain.
Citation:
HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. 2001, 40 (2):110-8 Curr. Genet.
Journal:
Current Genetics
Issue Date:
Sep-2001
URI:
http://hdl.handle.net/10541/85758
DOI:
10.1007/s002940100241
PubMed ID:
11680820
Type:
Article
Language:
en
ISSN:
0172-8083
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSánchez-Díaz, Albertoen
dc.contributor.authorBlanco, Miguel Aen
dc.contributor.authorJones, Nicen
dc.contributor.authorMoreno, Sergioen
dc.date.accessioned2009-11-10T10:23:13Z-
dc.date.available2009-11-10T10:23:13Z-
dc.date.issued2001-09-
dc.identifier.citationHBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. 2001, 40 (2):110-8 Curr. Genet.en
dc.identifier.issn0172-8083-
dc.identifier.pmid11680820-
dc.identifier.doi10.1007/s002940100241-
dc.identifier.urihttp://hdl.handle.net/10541/85758-
dc.description.abstractThe mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates CdclO-dependent transcription at G1/S and allows growth of cdc10-129, resldelta and rep2delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.en
dc.language.isoenen
dc.subject.meshAmino Acid Sequence-
dc.subject.meshAnimals-
dc.subject.meshCell Cycle Proteins-
dc.subject.meshCloning, Molecular-
dc.subject.meshG1 Phase-
dc.subject.meshGTP Phosphohydrolases-
dc.subject.meshGenetic Complementation Test-
dc.subject.meshHMG-Box Domains-
dc.subject.meshHumans-
dc.subject.meshMammals-
dc.subject.meshMembrane Proteins-
dc.subject.meshMice-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshMutation-
dc.subject.meshNuclear Localization Signals-
dc.subject.meshS Phase-
dc.subject.meshSaccharomyces cerevisiae Proteins-
dc.subject.meshSchizosaccharomyces-
dc.subject.meshSchizosaccharomyces pombe Proteins-
dc.subject.meshSequence Homology, Amino Acid-
dc.subject.meshTrans-Activators-
dc.subject.meshTranscription Factors-
dc.titleHBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.en
dc.typeArticleen
dc.contributor.departmentInstituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genética, CSIC/Universidad de Salamanca, Spain.en
dc.identifier.journalCurrent Geneticsen

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