2.50
Hdl Handle:
http://hdl.handle.net/10541/85740
Title:
Redox control of AP-1-like factors in yeast and beyond.
Authors:
Toone, W Mark; Morgan, Brian A; Jones, Nic
Abstract:
Cells have evolved complex and efficient strategies for dealing with variable and often-harsh environments. A key aspect of these stress responses is the transcriptional activation of genes encoding defense and repair proteins. In yeast members of the AP-1 family of proteins are required for the transcriptional response to oxidative stress. This sub-family of AP-1 (called yAP-1) proteins are sensors of the redox-state of the cell and are activated directly by oxidative stress conditions. yAP-1 proteins are bZIP-containing factors that share homology to the mammalian AP-1 factor complex and bind to very similar DNA sequence sites. The generation of reactive oxygen species and the resulting potential for oxidative stress is common to all aerobically growing organisms. Furthermore, many of the features of this response appear to be evolutionarily conserved and consequently the study of model organisms, such as yeast, will have widespread utility. The important structural features of these factors, signaling pathways controlling their activity and the nature of the target genes they control will be discussed.
Affiliation:
CRC Cell Regulation Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.
Citation:
Redox control of AP-1-like factors in yeast and beyond. 2001, 20 (19):2336-46 Oncogene
Journal:
Oncogene
Issue Date:
30-Apr-2001
URI:
http://hdl.handle.net/10541/85740
DOI:
10.1038/sj.onc.1204384
PubMed ID:
11402331
Type:
Article
Language:
en
ISSN:
0950-9232
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorToone, W Marken
dc.contributor.authorMorgan, Brian Aen
dc.contributor.authorJones, Nicen
dc.date.accessioned2009-11-10T10:39:34Z-
dc.date.available2009-11-10T10:39:34Z-
dc.date.issued2001-04-30-
dc.identifier.citationRedox control of AP-1-like factors in yeast and beyond. 2001, 20 (19):2336-46 Oncogeneen
dc.identifier.issn0950-9232-
dc.identifier.pmid11402331-
dc.identifier.doi10.1038/sj.onc.1204384-
dc.identifier.urihttp://hdl.handle.net/10541/85740-
dc.description.abstractCells have evolved complex and efficient strategies for dealing with variable and often-harsh environments. A key aspect of these stress responses is the transcriptional activation of genes encoding defense and repair proteins. In yeast members of the AP-1 family of proteins are required for the transcriptional response to oxidative stress. This sub-family of AP-1 (called yAP-1) proteins are sensors of the redox-state of the cell and are activated directly by oxidative stress conditions. yAP-1 proteins are bZIP-containing factors that share homology to the mammalian AP-1 factor complex and bind to very similar DNA sequence sites. The generation of reactive oxygen species and the resulting potential for oxidative stress is common to all aerobically growing organisms. Furthermore, many of the features of this response appear to be evolutionarily conserved and consequently the study of model organisms, such as yeast, will have widespread utility. The important structural features of these factors, signaling pathways controlling their activity and the nature of the target genes they control will be discussed.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBase Sequence-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshEvolution, Molecular-
dc.subject.meshModels, Biological-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshOxidation-Reduction-
dc.subject.meshOxidative Stress-
dc.subject.meshReactive Oxygen Species-
dc.subject.meshSaccharomyces cerevisiae Proteins-
dc.subject.meshSequence Homology, Nucleic Acid-
dc.subject.meshSignal Transduction-
dc.subject.meshThioredoxins-
dc.subject.meshTranscription Factor AP-1-
dc.subject.meshTranscription Factors-
dc.subject.meshTranscriptional Activation-
dc.subject.meshYeasts-
dc.titleRedox control of AP-1-like factors in yeast and beyond.en
dc.typeArticleen
dc.contributor.departmentCRC Cell Regulation Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.en
dc.identifier.journalOncogeneen

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