Cell migration and organization in the intestinal crypt using a lattice-free model.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85731
Title:
Cell migration and organization in the intestinal crypt using a lattice-free model.
Authors:
Meineke, F A; Potten, Christopher S; Loeffler, M
Abstract:
We present a novel class of spatial models of cell movement and arrangement applied to the two-dimensional cellular organization of the intestinal crypt. The model differs from earlier approaches in using a dynamic movement on a lattice-free cylindrical surface. Cell movement is a consequence of mitotic activity. Cells interact by viscoelastic forces. Voronoi tessellation permits simulations of individual cell boundaries. Simulations can be compared with experimental data obtained from cell scoring in sections. Simulation studies show that the model is consistent with the experimental results for the spatial distribution of labelling indices, mitotic indices and other observed phenomena using a fixed number of stem cells and a fixed number of transit cell divisions.
Affiliation:
Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany. meineke@imise.uni-leipzig.de
Citation:
Cell migration and organization in the intestinal crypt using a lattice-free model. 2001, 34 (4):253-66 Cell Prolif.
Journal:
Cell Proliferation
Issue Date:
Aug-2001
URI:
http://hdl.handle.net/10541/85731
PubMed ID:
11529883
Type:
Article
Language:
en
ISSN:
0960-7722
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMeineke, F Aen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorLoeffler, Men
dc.date.accessioned2009-11-10T10:05:34Z-
dc.date.available2009-11-10T10:05:34Z-
dc.date.issued2001-08-
dc.identifier.citationCell migration and organization in the intestinal crypt using a lattice-free model. 2001, 34 (4):253-66 Cell Prolif.en
dc.identifier.issn0960-7722-
dc.identifier.pmid11529883-
dc.identifier.urihttp://hdl.handle.net/10541/85731-
dc.description.abstractWe present a novel class of spatial models of cell movement and arrangement applied to the two-dimensional cellular organization of the intestinal crypt. The model differs from earlier approaches in using a dynamic movement on a lattice-free cylindrical surface. Cell movement is a consequence of mitotic activity. Cells interact by viscoelastic forces. Voronoi tessellation permits simulations of individual cell boundaries. Simulations can be compared with experimental data obtained from cell scoring in sections. Simulation studies show that the model is consistent with the experimental results for the spatial distribution of labelling indices, mitotic indices and other observed phenomena using a fixed number of stem cells and a fixed number of transit cell divisions.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Communication-
dc.subject.meshCell Movement-
dc.subject.meshComputer Simulation-
dc.subject.meshElasticity-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMitosis-
dc.subject.meshModels, Biological-
dc.subject.meshPaneth Cells-
dc.subject.meshReproducibility of Results-
dc.subject.meshViscosity-
dc.titleCell migration and organization in the intestinal crypt using a lattice-free model.en
dc.typeArticleen
dc.contributor.departmentInstitute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany. meineke@imise.uni-leipzig.deen
dc.identifier.journalCell Proliferationen
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