Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85724
Title:
Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.
Authors:
O'Connor, Peter J; MacNaught, F; Butler, W H; Cooper, Donald P; Margison, Geoffrey P; Povey, Andrew C
Abstract:
Ivermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.
Affiliation:
Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine. 2001, 20 (3):223-7 J. Environ. Pathol. Toxicol. Oncol.
Journal:
Journal of Environmental Pathology, Toxicology and Oncology
Issue Date:
2001
URI:
http://hdl.handle.net/10541/85724
PubMed ID:
11797831
Type:
Article
Language:
en
ISSN:
0731-8898
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connor, Peter Jen
dc.contributor.authorMacNaught, Fen
dc.contributor.authorButler, W Hen
dc.contributor.authorCooper, Donald Pen
dc.contributor.authorMargison, Geoffrey Pen
dc.contributor.authorPovey, Andrew Cen
dc.date.accessioned2009-11-10T09:48:20Z-
dc.date.available2009-11-10T09:48:20Z-
dc.date.issued2001-
dc.identifier.citationIncreased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine. 2001, 20 (3):223-7 J. Environ. Pathol. Toxicol. Oncol.en
dc.identifier.issn0731-8898-
dc.identifier.pmid11797831-
dc.identifier.urihttp://hdl.handle.net/10541/85724-
dc.description.abstractIvermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.en
dc.language.isoenen
dc.subjectStomach Canceren
dc.subject.meshAdministration, Oral-
dc.subject.meshAnimals-
dc.subject.meshDiet-
dc.subject.meshDrug Interactions-
dc.subject.meshInsecticides-
dc.subject.meshIvermectin-
dc.subject.meshMale-
dc.subject.meshMethylnitronitrosoguanidine-
dc.subject.meshMutagens-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.subject.meshSeverity of Illness Index-
dc.subject.meshStomach Neoplasms-
dc.titleIncreased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalJournal of Environmental Pathology, Toxicology and Oncologyen
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