Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85722
Title:
Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.
Authors:
Morton, Colin A; Whitehurst, Colin; McColl, John H; Moore, James V; MacKie, Rona M
Abstract:
BACKGROUND: Photodynamic therapy (PDT) using topical delta-aminolevulinic acid (delta-ALA) is an effective treatment for Bowen disease and certain basal cell carcinomas (BCCs), but its place in clinical practice remains to be established. Patients with large and/or multiple lesions of Bowen disease or BCC can represent a considerable therapeutic challenge. We suggest that delta-ALA PDT may be of particular benefit in such patients. OBSERVATION: In an open study, 35 (88%) of 40 large patches of Bowen disease, all with a maximum diameter greater than 20 mm, cleared following 1 to 3 treatments of delta-ALA PDT, although 4 patches recurred within 12 months. delta-Aminolevulinic acid PDT was also used to treat 40 large BCCs, with an identical 88% initial clearance (after 1-3 treatments), with 4 recurrences within 34 months (range, 12-60 months). In 10 further patients with multiple (> or =3) patches of Bowen disease, 44 (98%) of 45 patches cleared following delta-ALA PDT, although 4 lesions recurred over 12 months. In 3 patients with multiple BCCs, PDT cleared 52 (90%) of 58 lesions, with 2 recurrences during 41 months (range, 12-52 months). Treatments were well tolerated, with only 5 patients with solitary large lesions requiring local anesthesia. CONCLUSIONS: delta-Aminolevulinic acid PDT is an effective tissue-sparing modality achieving good cosmesis. We propose that delta-ALA PDT be considered as a first-line therapy for large and/or multiple areas of Bowen disease and superficial BCCs.
Affiliation:
University Department of Dermatology, Western Infirmary, University of Glasgow, Scotland. colin.morton@fvah.scot.nhs.uk
Citation:
Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. 2001, 137 (3):319-24 Arch Dermatol
Journal:
Archives of Dermatology
Issue Date:
Mar-2001
URI:
http://hdl.handle.net/10541/85722
PubMed ID:
11255332
Type:
Article
Language:
en
ISSN:
0003-987X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMorton, Colin Aen
dc.contributor.authorWhitehurst, Colinen
dc.contributor.authorMcColl, John Hen
dc.contributor.authorMoore, James Ven
dc.contributor.authorMacKie, Rona Men
dc.date.accessioned2009-11-10T09:42:46Z-
dc.date.available2009-11-10T09:42:46Z-
dc.date.issued2001-03-
dc.identifier.citationPhotodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. 2001, 137 (3):319-24 Arch Dermatolen
dc.identifier.issn0003-987X-
dc.identifier.pmid11255332-
dc.identifier.urihttp://hdl.handle.net/10541/85722-
dc.description.abstractBACKGROUND: Photodynamic therapy (PDT) using topical delta-aminolevulinic acid (delta-ALA) is an effective treatment for Bowen disease and certain basal cell carcinomas (BCCs), but its place in clinical practice remains to be established. Patients with large and/or multiple lesions of Bowen disease or BCC can represent a considerable therapeutic challenge. We suggest that delta-ALA PDT may be of particular benefit in such patients. OBSERVATION: In an open study, 35 (88%) of 40 large patches of Bowen disease, all with a maximum diameter greater than 20 mm, cleared following 1 to 3 treatments of delta-ALA PDT, although 4 patches recurred within 12 months. delta-Aminolevulinic acid PDT was also used to treat 40 large BCCs, with an identical 88% initial clearance (after 1-3 treatments), with 4 recurrences within 34 months (range, 12-60 months). In 10 further patients with multiple (> or =3) patches of Bowen disease, 44 (98%) of 45 patches cleared following delta-ALA PDT, although 4 lesions recurred over 12 months. In 3 patients with multiple BCCs, PDT cleared 52 (90%) of 58 lesions, with 2 recurrences during 41 months (range, 12-52 months). Treatments were well tolerated, with only 5 patients with solitary large lesions requiring local anesthesia. CONCLUSIONS: delta-Aminolevulinic acid PDT is an effective tissue-sparing modality achieving good cosmesis. We propose that delta-ALA PDT be considered as a first-line therapy for large and/or multiple areas of Bowen disease and superficial BCCs.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectMultiple Primary Canceren
dc.subjectSkin Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAminolevulinic Acid-
dc.subject.meshBowen's Disease-
dc.subject.meshCarcinoma, Basal Cell-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshNeoplasms, Multiple Primary-
dc.subject.meshPhotochemotherapy-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshSkin Neoplasms-
dc.titlePhotodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Dermatology, Western Infirmary, University of Glasgow, Scotland. colin.morton@fvah.scot.nhs.uken
dc.identifier.journalArchives of Dermatologyen
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