Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85719
Title:
Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.
Authors:
Lawrence, Nicholas J; McGown, Alan T; Nduka, Jane; Hadfield, John A; Pritchard, Robin G
Abstract:
Two series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.
Affiliation:
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk
Citation:
Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.
Journal:
Bioorganic & Medicinal Chemistry Letters
Issue Date:
12-Feb-2001
URI:
http://hdl.handle.net/10541/85719
PubMed ID:
11212128
Type:
Article
Language:
en
ISSN:
0960-894X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLawrence, Nicholas Jen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorNduka, Janeen
dc.contributor.authorHadfield, John Aen
dc.contributor.authorPritchard, Robin Gen
dc.date.accessioned2009-11-10T09:33:21Z-
dc.date.available2009-11-10T09:33:21Z-
dc.date.issued2001-02-12-
dc.identifier.citationCytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X-
dc.identifier.pmid11212128-
dc.identifier.urihttp://hdl.handle.net/10541/85719-
dc.description.abstractTwo series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.en
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subject.meshAmines-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshApoptosis-
dc.subject.meshCell Cycle-
dc.subject.meshCell Division-
dc.subject.meshCombinatorial Chemistry Techniques-
dc.subject.meshHumans-
dc.subject.meshInhibitory Concentration 50-
dc.subject.meshK562 Cells-
dc.subject.meshLactones-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshTumor Cells, Cultured-
dc.titleCytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uken
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen

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