Tumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85607
Title:
Tumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients.
Authors:
Kim, Joo-Young; Cho, Hyun Yee; Lee, Kyu Chan; Hwang, You Jin; Lee, Myung Hak; Roberts, Stephen A; Kim, Chul-Hwan
Abstract:
To investigate tumor apoptosis as a prognostic factor for outcome following radiation therapy, comparisons were made of apoptotic index (AI) as a predictor of short- vs. long-term response and pretreatment vs. radiation-induced apoptosis. Forty-two patients with proven squamous cell carcinoma of the uterine cervix were treated by radiation alone. Apoptosis was measured by light microscopic observation of hematoxylin and eosin-stained sections from biopsies taken before treatment and 4 and 24 hr after 2 Gy. Patients were evaluated at the end of the external radiation for determination of short-term response and for long-term outcome as well (median follow-up of 27 months). Patients with high spontaneous AI showed poor short-term response, local control, and survival. The significance of AI as a predictor of short-term response was lost after allowing for differences in tumor size. The positive predictive value of AI for local control and survival was independent of tumor size and stage. High AI was associated with poor local control and long-term prognosis in advanced squamous cell carcinoma of the cervix. The in vivo radiation-induced AI after 4 or 24 hr did not predict radiation therapy outcome.
Affiliation:
Department of Radiation Oncology, Gil Medical Center, Gachon Medical College, Inchon, Korea.
Citation:
Tumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients. 2001, 96 (5):305-12 Int. J. Cancer
Journal:
International Journal of Cancer
Issue Date:
20-Oct-2001
URI:
http://hdl.handle.net/10541/85607
PubMed ID:
11582583
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorKim, Joo-Youngen
dc.contributor.authorCho, Hyun Yeeen
dc.contributor.authorLee, Kyu Chanen
dc.contributor.authorHwang, You Jinen
dc.contributor.authorLee, Myung Haken
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorKim, Chul-Hwanen
dc.date.accessioned2009-11-06T16:49:44Z-
dc.date.available2009-11-06T16:49:44Z-
dc.date.issued2001-10-20-
dc.identifier.citationTumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients. 2001, 96 (5):305-12 Int. J. Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid11582583-
dc.identifier.urihttp://hdl.handle.net/10541/85607-
dc.description.abstractTo investigate tumor apoptosis as a prognostic factor for outcome following radiation therapy, comparisons were made of apoptotic index (AI) as a predictor of short- vs. long-term response and pretreatment vs. radiation-induced apoptosis. Forty-two patients with proven squamous cell carcinoma of the uterine cervix were treated by radiation alone. Apoptosis was measured by light microscopic observation of hematoxylin and eosin-stained sections from biopsies taken before treatment and 4 and 24 hr after 2 Gy. Patients were evaluated at the end of the external radiation for determination of short-term response and for long-term outcome as well (median follow-up of 27 months). Patients with high spontaneous AI showed poor short-term response, local control, and survival. The significance of AI as a predictor of short-term response was lost after allowing for differences in tumor size. The positive predictive value of AI for local control and survival was independent of tumor size and stage. High AI was associated with poor local control and long-term prognosis in advanced squamous cell carcinoma of the cervix. The in vivo radiation-induced AI after 4 or 24 hr did not predict radiation therapy outcome.en
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshApoptosis-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshDisease-Free Survival-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMiddle Aged-
dc.subject.meshPrognosis-
dc.subject.meshTime Factors-
dc.subject.meshTreatment Outcome-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleTumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, Gil Medical Center, Gachon Medical College, Inchon, Korea.en
dc.identifier.journalInternational Journal of Canceren

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