Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85591
Title:
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Authors:
Lawrence, Nicholas J; Rennison, David; Woo, Meiki; McGown, Alan T; Hadfield, John A
Abstract:
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
Affiliation:
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk
Citation:
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. 2001, 11 (1):51-4 Bioorg. Med. Chem. Lett.
Journal:
Bioorganic & Medicinal Chemistry Letters
Issue Date:
8-Jan-2001
URI:
http://hdl.handle.net/10541/85591
PubMed ID:
11140732
Type:
Article
Language:
en
ISSN:
0960-894X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLawrence, Nicholas Jen
dc.contributor.authorRennison, Daviden
dc.contributor.authorWoo, Meikien
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorHadfield, John Aen
dc.date.accessioned2009-11-06T16:42:26Z-
dc.date.available2009-11-06T16:42:26Z-
dc.date.issued2001-01-08-
dc.identifier.citationAntimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. 2001, 11 (1):51-4 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X-
dc.identifier.pmid11140732-
dc.identifier.urihttp://hdl.handle.net/10541/85591-
dc.description.abstractA series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.en
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshCell Cycle-
dc.subject.meshCell Division-
dc.subject.meshColchicine-
dc.subject.meshEthers-
dc.subject.meshHumans-
dc.subject.meshInhibitory Concentration 50-
dc.subject.meshMolecular Structure-
dc.subject.meshPlants, Medicinal-
dc.subject.meshProtein Binding-
dc.subject.meshStilbenes-
dc.subject.meshTubulin-
dc.subject.meshTumor Cells, Cultured-
dc.titleAntimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uken
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen

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