2.50
Hdl Handle:
http://hdl.handle.net/10541/85580
Title:
Prospects for gene therapy using haemopoietic stem cells.
Authors:
Fairbairn, Leslie J; Ewing, Joanne
Abstract:
Gene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.
Affiliation:
Cancer Research Campaign Gene Therapy Group, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Prospects for gene therapy using haemopoietic stem cells. 2001, 14 (4):823-34 Best Pract Res Clin Haematol
Journal:
Best Practice & Research. Clinical Haematology
Issue Date:
Dec-2001
URI:
http://hdl.handle.net/10541/85580
DOI:
10.1053/beha.2001.0175
PubMed ID:
11924924
Type:
Article
Language:
en
ISSN:
1521-6926
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFairbairn, Leslie Jen
dc.contributor.authorEwing, Joanneen
dc.date.accessioned2009-11-06T16:07:16Z-
dc.date.available2009-11-06T16:07:16Z-
dc.date.issued2001-12-
dc.identifier.citationProspects for gene therapy using haemopoietic stem cells. 2001, 14 (4):823-34 Best Pract Res Clin Haematolen
dc.identifier.issn1521-6926-
dc.identifier.pmid11924924-
dc.identifier.doi10.1053/beha.2001.0175-
dc.identifier.urihttp://hdl.handle.net/10541/85580-
dc.description.abstractGene therapy has thus far promised much and delivered little. Much of this has been due to deficiencies in the reagents and methodologies employed in early clinical trials. Recent technological advances in vectors and haemopoietic stem cell manipulation, coupled with improved pre-clinical assays of gene transfer and expression in re-populating stem cells give cause for greater optimism. Here we review these advances and indicate areas requiring further development before clinical gene therapy in the haemopoietic system becomes a widely applicable treatment modality.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cells-
dc.subject.meshAnimals-
dc.subject.meshGene Therapy-
dc.subject.meshGenetic Vectors-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHumans-
dc.subject.meshTransduction, Genetic-
dc.titleProspects for gene therapy using haemopoietic stem cells.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Gene Therapy Group, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalBest Practice & Research. Clinical Haematologyen

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