Chromosomal radiosensitivity as a marker of predisposition to common cancers?

2.50
Hdl Handle:
http://hdl.handle.net/10541/85567
Title:
Chromosomal radiosensitivity as a marker of predisposition to common cancers?
Authors:
Baria, K; Warren, C; Roberts, Stephen A; West, Catharine M L; Scott, David
Abstract:
We previously found that 40% of breast cancer patients showed enhanced sensitivity to X-ray induced chromosome damage in G(2)lymphocytes and suggested that this might indicate a low penetrance predisposition to breast cancer, for which there is good epidemiological evidence. We have now tested the hypothesis that elevated G(2)radiosensitivity is a marker of such predisposition to other common cancers. We tested patients with colorectal cancer, for which there is also good epidemiological evidence of inherited risk in a substantial proportion of cases, and patients with cancers having a strong environmental aetiology (lung and cervix). We also repeated our study of breast cancer cases and tested patients with chronic diseases other than cancer. The results support our hypothesis, in that 30% (12/37) of colorectal cases showed enhanced sensitivity compared with 9% (6/66) of normal healthy controls (P = 0.01), whereas the proportions of sensitive cervix (11%, 3/27, P = 0.72) and lung cancer cases (23%, 8/35, P = 0.07) were not significantly above normals. We confirmed the enhanced sensitivity of 40% (12/31, P = 0.001) of breast cancer patients and found that patients with non-malignant disease had a normal response in the assay (12%, 4/34, P = 0.73). We suggest that enhanced G(2)chromosomal radiosensitivity is a consequence of inherited defects in the ability of cells to process DNA damage from endogenous or exogenous sources, of a type that is mimicked by ionizing radiation, and that such defects predispose to breast and colorectal cancer.
Affiliation:
CRC Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.
Citation:
Chromosomal radiosensitivity as a marker of predisposition to common cancers? 2001, 84 (7):892-6 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
6-Apr-2001
URI:
http://hdl.handle.net/10541/85567
DOI:
10.1054/bjoc.2000.1701
PubMed ID:
11286467
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBaria, Ken
dc.contributor.authorWarren, Cen
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorScott, Daviden
dc.date.accessioned2009-11-06T15:08:45Z-
dc.date.available2009-11-06T15:08:45Z-
dc.date.issued2001-04-06-
dc.identifier.citationChromosomal radiosensitivity as a marker of predisposition to common cancers? 2001, 84 (7):892-6 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid11286467-
dc.identifier.doi10.1054/bjoc.2000.1701-
dc.identifier.urihttp://hdl.handle.net/10541/85567-
dc.description.abstractWe previously found that 40% of breast cancer patients showed enhanced sensitivity to X-ray induced chromosome damage in G(2)lymphocytes and suggested that this might indicate a low penetrance predisposition to breast cancer, for which there is good epidemiological evidence. We have now tested the hypothesis that elevated G(2)radiosensitivity is a marker of such predisposition to other common cancers. We tested patients with colorectal cancer, for which there is also good epidemiological evidence of inherited risk in a substantial proportion of cases, and patients with cancers having a strong environmental aetiology (lung and cervix). We also repeated our study of breast cancer cases and tested patients with chronic diseases other than cancer. The results support our hypothesis, in that 30% (12/37) of colorectal cases showed enhanced sensitivity compared with 9% (6/66) of normal healthy controls (P = 0.01), whereas the proportions of sensitive cervix (11%, 3/27, P = 0.72) and lung cancer cases (23%, 8/35, P = 0.07) were not significantly above normals. We confirmed the enhanced sensitivity of 40% (12/31, P = 0.001) of breast cancer patients and found that patients with non-malignant disease had a normal response in the assay (12%, 4/34, P = 0.73). We suggest that enhanced G(2)chromosomal radiosensitivity is a consequence of inherited defects in the ability of cells to process DNA damage from endogenous or exogenous sources, of a type that is mimicked by ionizing radiation, and that such defects predispose to breast and colorectal cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectColorectal Canceren
dc.subjectLung Canceren
dc.subjectCanceren
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChromosome Aberrations-
dc.subject.meshChromosomes, Human-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshG2 Phase-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms-
dc.subject.meshRadiation Tolerance-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleChromosomal radiosensitivity as a marker of predisposition to common cancers?en
dc.typeArticleen
dc.contributor.departmentCRC Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.en
dc.identifier.journalBritish Journal of Canceren
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