2.50
Hdl Handle:
http://hdl.handle.net/10541/85552
Title:
Consequential late effects in normal tissues.
Authors:
Dörr, Wolfgang; Hendry, Jolyon H
Abstract:
Unconventional, more aggressive irradiation protocols are usually associated with aggravation of acute reactions. In recent clinical studies, this has resulted in modulation of late effects in the same organ. This phenomenon has been termed consequential late effect (CLE). Correlations between acute and late effects have been reported in a number of tissues. Moreover, some radiobiological parameters may be used to differentiate between consequential and generic late effects: Dose fractionation and overall treatment time have a similar effect on acute and consequential responses, but opposing effects on generic late effects. Modulation of acute effects will affect the consequential component of late sequelae. Similarly, it will be influenced by the irradiated volume if a volume effect exists for the acute response. Moreover, markers for the acute response should be predictive for consequential effects. The present review gives preclinical and clinical evidence for CLE. These are predominantly found in organ systems where the acute response (of the epithelial lining) is associated with an impairment of the barrier against mechanical or chemical stress, which may cause additional trauma to the underlying tissues. Therefore, CLE are mainly found in the urinary and intestinal system, in mucosa and, to some extent, in skin. In these tissues with a consequential component of the late sequelae, amelioration of the acute response to irradiation may be a useful approach to minimize late side effects of effective radiation therapy.
Affiliation:
Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, D-01 307 Dresden, Germany.
Citation:
Consequential late effects in normal tissues. 2001, 61 (3):223-31 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Dec-2001
URI:
http://hdl.handle.net/10541/85552
PubMed ID:
11730991
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDörr, Wolfgangen
dc.contributor.authorHendry, Jolyon Hen
dc.date.accessioned2009-11-06T15:40:11Z-
dc.date.available2009-11-06T15:40:11Z-
dc.date.issued2001-12-
dc.identifier.citationConsequential late effects in normal tissues. 2001, 61 (3):223-31 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid11730991-
dc.identifier.urihttp://hdl.handle.net/10541/85552-
dc.description.abstractUnconventional, more aggressive irradiation protocols are usually associated with aggravation of acute reactions. In recent clinical studies, this has resulted in modulation of late effects in the same organ. This phenomenon has been termed consequential late effect (CLE). Correlations between acute and late effects have been reported in a number of tissues. Moreover, some radiobiological parameters may be used to differentiate between consequential and generic late effects: Dose fractionation and overall treatment time have a similar effect on acute and consequential responses, but opposing effects on generic late effects. Modulation of acute effects will affect the consequential component of late sequelae. Similarly, it will be influenced by the irradiated volume if a volume effect exists for the acute response. Moreover, markers for the acute response should be predictive for consequential effects. The present review gives preclinical and clinical evidence for CLE. These are predominantly found in organ systems where the acute response (of the epithelial lining) is associated with an impairment of the barrier against mechanical or chemical stress, which may cause additional trauma to the underlying tissues. Therefore, CLE are mainly found in the urinary and intestinal system, in mucosa and, to some extent, in skin. In these tissues with a consequential component of the late sequelae, amelioration of the acute response to irradiation may be a useful approach to minimize late side effects of effective radiation therapy.en
dc.language.isoenen
dc.subject.meshDigestive System-
dc.subject.meshHumans-
dc.subject.meshRadiation Injuries-
dc.subject.meshRadiobiology-
dc.subject.meshRadiotherapy-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshSkin-
dc.subject.meshSoft Tissue Injuries-
dc.subject.meshTime Factors-
dc.subject.meshUrogenital System-
dc.titleConsequential late effects in normal tissues.en
dc.typeArticleen
dc.contributor.departmentKlinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, D-01 307 Dresden, Germany.en
dc.identifier.journalRadiotherapy and Oncologyen

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