2.50
Hdl Handle:
http://hdl.handle.net/10541/85531
Title:
Ovarian steroids and control of proliferation in the normal human breast.
Authors:
Anderson, Elizabeth
Abstract:
Until recently, there has been considerable uncertainty as to how, or even which of the ovarian steroids influence human breast luminal epithelial cell proliferation. It is important that this is known because increased proliferative activity of this particular cell population is associated with increased risk of breast cancer. Review of the available literature suggests that while oestradiol is the major steroid mitogen in pre-menopausal women, the role of progesterone becomes more significant after the menopause when oestradiol levels are reduced. Moreover, recent studies have given new insights into the mechanisms by which oestradiol and progesterone exert their effects. This knowledge may allow development of new strategies for predicting breast cancer risk or preventing the disease.
Affiliation:
Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK. eanderson@picr.man.ac.uk
Citation:
Ovarian steroids and control of proliferation in the normal human breast. 2001, 10 (4):273-8 Breast
Journal:
Breast
Issue Date:
Aug-2001
URI:
http://hdl.handle.net/10541/85531
DOI:
10.1054/brst.2000.0258
PubMed ID:
14965592
Type:
Article
Language:
en
ISSN:
0960-9776
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorAnderson, Elizabethen
dc.date.accessioned2009-11-06T11:28:43Z-
dc.date.available2009-11-06T11:28:43Z-
dc.date.issued2001-08-
dc.identifier.citationOvarian steroids and control of proliferation in the normal human breast. 2001, 10 (4):273-8 Breasten
dc.identifier.issn0960-9776-
dc.identifier.pmid14965592-
dc.identifier.doi10.1054/brst.2000.0258-
dc.identifier.urihttp://hdl.handle.net/10541/85531-
dc.description.abstractUntil recently, there has been considerable uncertainty as to how, or even which of the ovarian steroids influence human breast luminal epithelial cell proliferation. It is important that this is known because increased proliferative activity of this particular cell population is associated with increased risk of breast cancer. Review of the available literature suggests that while oestradiol is the major steroid mitogen in pre-menopausal women, the role of progesterone becomes more significant after the menopause when oestradiol levels are reduced. Moreover, recent studies have given new insights into the mechanisms by which oestradiol and progesterone exert their effects. This knowledge may allow development of new strategies for predicting breast cancer risk or preventing the disease.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectOvarian Steroidsen
dc.titleOvarian steroids and control of proliferation in the normal human breast.en
dc.typeArticleen
dc.contributor.departmentClinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK. eanderson@picr.man.ac.uken
dc.identifier.journalBreasten

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