New insights into heparan sulphate biosynthesis from the study of mutant mice.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85496
Title:
New insights into heparan sulphate biosynthesis from the study of mutant mice.
Authors:
Merry, Catherine L R; Gallagher, John T
Abstract:
Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS-ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st -/- mice.
Affiliation:
Cancer Research UK Department of Medical Oncology, Christie Research Centre, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, U.K. cmerry@picr.man.ac.uk
Citation:
New insights into heparan sulphate biosynthesis from the study of mutant mice. 2002 (69):47-57 Biochem. Soc. Symp.
Journal:
Biochemical Society Symposium
Issue Date:
2002
URI:
http://hdl.handle.net/10541/85496
PubMed ID:
12655773
Type:
Article
Language:
en
ISSN:
0067-8694
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMerry, Catherine L Ren
dc.contributor.authorGallagher, John Ten
dc.date.accessioned2009-11-06T09:14:36Z-
dc.date.available2009-11-06T09:14:36Z-
dc.date.issued2002-
dc.identifier.citationNew insights into heparan sulphate biosynthesis from the study of mutant mice. 2002 (69):47-57 Biochem. Soc. Symp.en
dc.identifier.issn0067-8694-
dc.identifier.pmid12655773-
dc.identifier.urihttp://hdl.handle.net/10541/85496-
dc.description.abstractHeparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS-ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st -/- mice.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCarbohydrate Sequence-
dc.subject.meshHeparitin Sulfate-
dc.subject.meshMice-
dc.subject.meshMice, Mutant Strains-
dc.subject.meshMolecular Sequence Data-
dc.titleNew insights into heparan sulphate biosynthesis from the study of mutant mice.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Christie Research Centre, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, U.K. cmerry@picr.man.ac.uken
dc.identifier.journalBiochemical Society Symposiumen

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