O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85476
Title:
O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.
Authors:
Margison, Geoffrey P; Santibanez-Koref, Mauro F
Abstract:
The DNA in human cells is continuously undergoing damage as consequences of both endogenous processes and exposure to exogenous agents. The resulting structural changes can be repaired by a number of systems that function to preserve genome integrity. Most pathways are multicomponent, involving incision in the damaged DNA strand and resynthesis using the undamaged strand as a template. In contrast, O(6)-alkylguanine-DNA alkyltransferase is able to act as a single protein that reverses specific types of alkylation damage simply by removing the offending alkyl group, which becomes covalently attached to the protein and inactivates it. The types of damage that ATase repairs are potentially toxic, mutagenic, recombinogenic and clastogenic. They are generated by certain classes of carcinogenic and chemotherapeutic alkylating agents. There is consequently a great deal of interest in this repair system in relation to both carcinogenesis and cancer chemotherapy.
Affiliation:
CRC Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. 2002, 24 (3):255-66 Bioessays
Journal:
BioEssays
Issue Date:
Mar-2002
URI:
http://hdl.handle.net/10541/85476
DOI:
10.1002/bies.10063
PubMed ID:
11891762
Type:
Article
Language:
en
ISSN:
0265-9247
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMargison, Geoffrey Pen
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.date.accessioned2009-11-05T17:27:39Z-
dc.date.available2009-11-05T17:27:39Z-
dc.date.issued2002-03-
dc.identifier.citationO6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. 2002, 24 (3):255-66 Bioessaysen
dc.identifier.issn0265-9247-
dc.identifier.pmid11891762-
dc.identifier.doi10.1002/bies.10063-
dc.identifier.urihttp://hdl.handle.net/10541/85476-
dc.description.abstractThe DNA in human cells is continuously undergoing damage as consequences of both endogenous processes and exposure to exogenous agents. The resulting structural changes can be repaired by a number of systems that function to preserve genome integrity. Most pathways are multicomponent, involving incision in the damaged DNA strand and resynthesis using the undamaged strand as a template. In contrast, O(6)-alkylguanine-DNA alkyltransferase is able to act as a single protein that reverses specific types of alkylation damage simply by removing the offending alkyl group, which becomes covalently attached to the protein and inactivates it. The types of damage that ATase repairs are potentially toxic, mutagenic, recombinogenic and clastogenic. They are generated by certain classes of carcinogenic and chemotherapeutic alkylating agents. There is consequently a great deal of interest in this repair system in relation to both carcinogenesis and cancer chemotherapy.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAlkylating Agents-
dc.subject.meshAnimals-
dc.subject.meshCarcinogens-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshDNA Repair-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase-
dc.titleO6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.en
dc.typeArticleen
dc.contributor.departmentCRC Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalBioEssaysen
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