The Scottish and Manchester randomised trial of neo-adjuvant chemotherapy for advanced cervical cancer.
Authors
Symonds, R PHabeshaw, T
Reed, N S
Paul, J
Pyper, E
Yosef, H
Davis, J
Hunter, Robin D
Davidson, Susan E
Stewart, Alan L
Cowie, V
Sarkar, T
Affiliation
Beatson Oncology Centre, Western Infirmary, Glasgow, UK. psymonds@uhl.trent.nhs.ukIssue Date
2000-05
Metadata
Show full item recordAbstract
204 eligible patients were entered into a multicentre randomised trial of neo-adjuvant chemotherapy prior to radical radiotherapy. The aim of this study was to assess whether there was any survival advantage in patients undergoing chemotherapy and radiotherapy compared with those given radiotherapy alone. Patients were aged up to 70 years, performance status 0-1/2, with bulky stage IIb, stage III or stage IVa squamous or adenosquamous carcinoma. Three cycles of methotrexate 100 mg/m2 and cisplatin 50 mg/m2 were given at 2-weekly intervals before radical radiotherapy. 104 eligible patients received the combination treatment and 100 radiotherapy only. The two arms of the study were well balanced for tumour and patient characteristics. The response rate to chemotherapy was 49%, 33% of patients in the radiotherapy (XRT) alone arm and 45% of the combination arm were clinically free of tumour at the end of treatment. The median follow-up for surviving patients is 5.4 years (range: 11 months-8 years) and 84% have been followed-up for more than 4 years. 134 patients have died (68 XRT only, 66 combined arm). The median survival RT alone was 111 weeks (95% confidence interval (CI) 72-151 weeks), combination arm 125 weeks (95% CI 79-170 weeks). The estimated death ratio is 0.79 (P = 0.19, 95% CI 0.56-1.12). The estimated 3-year survival is 40% (95% CI 30-50%) RT only compared with 47% (95% CI 37-57%) in the combination arm. Acute and late toxicity of radiotherapy was not increased by the addition of chemotherapy.Citation
The Scottish and Manchester randomised trial of neo-adjuvant chemotherapy for advanced cervical cancer. 2000, 36 (8):994-1001 Eur. J. CancerJournal
European Journal of CancerDOI
10.1016/S0959-8049(00)00034-4PubMed ID
10885603Type
ArticleLanguage
enISSN
0959-8049ae974a485f413a2113503eed53cd6c53
10.1016/S0959-8049(00)00034-4
Scopus Count
Collections
Related articles
- A randomised, prospective, phase III clinical trial of primary bleomycin, ifosfamide and cisplatin (BIP) chemotherapy followed by radiotherapy versus radiotherapy alone in inoperable cancer of the cervix.
- Authors: Herod J, Burton A, Buxton J, Tobias J, Luesley D, Jordan S, Dunn J, Poole CJ
- Issue date: 2000 Sep
- Recurrent cervical cancer treated with cisplatin and methotrexate.
- Authors: Obasaju CK, Cowan RA, Wilkinson PM
- Issue date: 1993
- Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: follow-up of a Gynecologic Oncology Group trial.
- Authors: Stehman FB, Ali S, Keys HM, Muderspach LI, Chafe WE, Gallup DG, Walker JL, Gersell D
- Issue date: 2007 Nov
- Weekly topotecan and cisplatin (TOPOCIS) as neo-adjuvant chemotherapy for locally-advanced squamous cervical carcinoma: Results of a phase II multicentric study.
- Authors: Zanaboni F, Grijuela B, Giudici S, Cormio G, Babilonti L, Ghezzi F, Giorda G, Scambia G, Franchi M, Lorusso M, Ditto A, Lorusso D, Raspagliesi F
- Issue date: 2013 Mar
- A feasibility study of topotecan with standard-dose cisplatin and concurrent primary radiation therapy in locally advanced cervical cancer.
- Authors: Gatcliffe TA, Tewari KS, Shah A, Brewster WR, Burger RA, Kuo JV, Monk BJ
- Issue date: 2009 Jan