Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85410
Title:
Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index.
Authors:
Harriss, D J; Atkinson, G; George, K; Cable, N Tim; Reilly, Thomas; Haboubi, Najib; Zwahlen, Marcel; Egger, Matthias; Renehan, Andrew G
Abstract:
OBJECTIVE: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. METHOD: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m(2) increase in BMI. RESULTS: We analysed 29 datasets from 28 articles, including 67,361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P < 0.001) and rectal (P = 0.005) cancers. Associations were generally consistent across geographic populations. Study characteristics and adjustments accounted for only moderate variations of associations. CONCLUSION: Increasing BMI is associated with a modest increased risk of developing colon and rectal cancers, but this modest risk may translate to large attributable proportions in high-prevalence obese populations. Inter-gender differences point to potentially important mechanistic differences, which merit further research.
Affiliation:
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Liverpool, UK.
Citation:
Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index. 2009, 11 (6):547-63 Colorectal Dis
Journal:
Colorectal Disease
Issue Date:
Jul-2009
URI:
http://hdl.handle.net/10541/85410
DOI:
10.1111/j.1463-1318.2009.01766.x
PubMed ID:
19207714
Type:
Article
Language:
en
ISSN:
1463-1318
Appears in Collections:
All Christie Publications ; Surgery

Full metadata record

DC FieldValue Language
dc.contributor.authorHarriss, D Jen
dc.contributor.authorAtkinson, Gen
dc.contributor.authorGeorge, Ken
dc.contributor.authorCable, N Timen
dc.contributor.authorReilly, Thomasen
dc.contributor.authorHaboubi, Najiben
dc.contributor.authorZwahlen, Marcelen
dc.contributor.authorEgger, Matthiasen
dc.contributor.authorRenehan, Andrew Gen
dc.date.accessioned2009-11-05T12:13:53Z-
dc.date.available2009-11-05T12:13:53Z-
dc.date.issued2009-07-
dc.identifier.citationLifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index. 2009, 11 (6):547-63 Colorectal Disen
dc.identifier.issn1463-1318-
dc.identifier.pmid19207714-
dc.identifier.doi10.1111/j.1463-1318.2009.01766.x-
dc.identifier.urihttp://hdl.handle.net/10541/85410-
dc.description.abstractOBJECTIVE: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. METHOD: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m(2) increase in BMI. RESULTS: We analysed 29 datasets from 28 articles, including 67,361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P < 0.001) and rectal (P = 0.005) cancers. Associations were generally consistent across geographic populations. Study characteristics and adjustments accounted for only moderate variations of associations. CONCLUSION: Increasing BMI is associated with a modest increased risk of developing colon and rectal cancers, but this modest risk may translate to large attributable proportions in high-prevalence obese populations. Inter-gender differences point to potentially important mechanistic differences, which merit further research.en
dc.language.isoenen
dc.subjectColonic Canceren
dc.subjectColorectal Canceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBody Mass Index-
dc.subject.meshColonic Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLife Style-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity-
dc.subject.meshOdds Ratio-
dc.subject.meshRisk Factors-
dc.subject.meshSex Factors-
dc.subject.meshYoung Adult-
dc.titleLifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index.en
dc.typeArticleen
dc.contributor.departmentResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Liverpool, UK.en
dc.identifier.journalColorectal Diseaseen

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