Micrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85404
Title:
Micrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma.
Authors:
Atula, T; Hunter, K D; Cooper, L A; Shoaib, T; Ross, Gary L; Soutar, D S
Abstract:
BACKGROUND: The occurrence of micrometastases (MMs) and isolated tumour cells (ITCs) in oral sentinel lymph node (SLN) biopsy is poorly known, and the definitions and clinical significance of MMs and ITCs in SLN biopsy are controversial. We compared the UICC/TNM definitions of MMs and ITCs with our previously published sentinel node protocol to assess how the adoption of the UICC/TNM criteria would affect the staging of nodal micrometastatic disease. METHODS: Of 107 patients who had a SLN biopsy and pathology at 150 microm intervals, 35 with metastatic tumour were included. Eighty-six SLNs were reassessed using the UICC/TNM definitions for MMs and ITCs. Findings were linked to the final pathology in the subsequent neck dissection. RESULTS: Initial H&E sections showed metastases in 24 patients (in 34 out of 61 SLN), 8 of whom (9 SLNs) had MMs. Additional step serial sections revealed metastatic deposits in a further 11 patients (15 out of 25 SLNs were positive) which were reassessed as MMs (6 patients) or ITCs (5 patients). Subsequent neck dissection revealed additional metastases in 46% of patients with MM, whilst one of the ITC patients had subsequent neck metastases (20%). CONCLUSION: Despite some limitations, the UICC/TNM classification provides an objective, uniform method of detecting MMs and ITC's. Unlike in cases with ITC, metastases in other non-SLNs were common when a micrometastasis was detected in a SLN, indicating need for further treatment of the neck.
Affiliation:
Canniesburn Plastic Surgery Unit, Jubilee Building, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, United Kingdom. timo.atula@hus.fi
Citation:
Micrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma. 2009, 35 (5):532-8 Eur J Surg Oncol
Journal:
European Journal of Surgical Oncology
Issue Date:
May-2009
URI:
http://hdl.handle.net/10541/85404
DOI:
10.1016/j.ejso.2008.12.014
PubMed ID:
19171449
Type:
Article
Language:
en
ISSN:
1532-2157
Appears in Collections:
All Christie Publications ; Surgery

Full metadata record

DC FieldValue Language
dc.contributor.authorAtula, Ten
dc.contributor.authorHunter, K Den
dc.contributor.authorCooper, L Aen
dc.contributor.authorShoaib, Ten
dc.contributor.authorRoss, Gary Len
dc.contributor.authorSoutar, D Sen
dc.date.accessioned2009-11-05T11:48:38Z-
dc.date.available2009-11-05T11:48:38Z-
dc.date.issued2009-05-
dc.identifier.citationMicrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma. 2009, 35 (5):532-8 Eur J Surg Oncolen
dc.identifier.issn1532-2157-
dc.identifier.pmid19171449-
dc.identifier.doi10.1016/j.ejso.2008.12.014-
dc.identifier.urihttp://hdl.handle.net/10541/85404-
dc.description.abstractBACKGROUND: The occurrence of micrometastases (MMs) and isolated tumour cells (ITCs) in oral sentinel lymph node (SLN) biopsy is poorly known, and the definitions and clinical significance of MMs and ITCs in SLN biopsy are controversial. We compared the UICC/TNM definitions of MMs and ITCs with our previously published sentinel node protocol to assess how the adoption of the UICC/TNM criteria would affect the staging of nodal micrometastatic disease. METHODS: Of 107 patients who had a SLN biopsy and pathology at 150 microm intervals, 35 with metastatic tumour were included. Eighty-six SLNs were reassessed using the UICC/TNM definitions for MMs and ITCs. Findings were linked to the final pathology in the subsequent neck dissection. RESULTS: Initial H&E sections showed metastases in 24 patients (in 34 out of 61 SLN), 8 of whom (9 SLNs) had MMs. Additional step serial sections revealed metastatic deposits in a further 11 patients (15 out of 25 SLNs were positive) which were reassessed as MMs (6 patients) or ITCs (5 patients). Subsequent neck dissection revealed additional metastases in 46% of patients with MM, whilst one of the ITC patients had subsequent neck metastases (20%). CONCLUSION: Despite some limitations, the UICC/TNM classification provides an objective, uniform method of detecting MMs and ITC's. Unlike in cases with ITC, metastases in other non-SLNs were common when a micrometastasis was detected in a SLN, indicating need for further treatment of the neck.en
dc.language.isoenen
dc.subjectOropharyngeal Canceren
dc.subjectCancer Stagingen
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshNeoplasm Staging-
dc.subject.meshOropharyngeal Neoplasms-
dc.subject.meshSentinel Lymph Node Biopsy-
dc.titleMicrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma.en
dc.typeArticleen
dc.contributor.departmentCanniesburn Plastic Surgery Unit, Jubilee Building, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, United Kingdom. timo.atula@hus.fien
dc.identifier.journalEuropean Journal of Surgical Oncologyen

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