An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry?

2.50
Hdl Handle:
http://hdl.handle.net/10541/85396
Title:
An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry?
Authors:
Salman, W D; Eyden, Brian P; Shelton, D; Howat, A; Al-Dawoud, A; Twaij, Z
Abstract:
Histopathologists in the current environment of medical negligence and litigation are more likely to use immunohistochemical investigations in their day-to-day practice to support their diagnosis and avoid future litigation. The caveat is that relying on immunohistochemistry is a double-edged sword and pathologists should be familiar with its limitations. We present a case of primary malignant peritoneal mesothelioma with an unusual immunohistochemical profile-desmin positive, EMA negative-and wish to highlight the importance of cautiously interpreting immunohistochemistry profiles when they do not fit the clinical history and histological appearance.
Affiliation:
East Lancashire Hospitals, UK. walidsalman@gmail.com
Citation:
An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry? 2009, 62 (7):651-2 J. Clin. Pathol.
Journal:
Journal of Clinical Pathology
Issue Date:
Jul-2009
URI:
http://hdl.handle.net/10541/85396
DOI:
10.1136/jcp.2008.061887
PubMed ID:
19561235
Type:
Article
Language:
en
ISSN:
1472-4146
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorSalman, W Den
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorShelton, Den
dc.contributor.authorHowat, Aen
dc.contributor.authorAl-Dawoud, Aen
dc.contributor.authorTwaij, Zen
dc.date.accessioned2009-11-05T10:36:09Z-
dc.date.available2009-11-05T10:36:09Z-
dc.date.issued2009-07-
dc.identifier.citationAn EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry? 2009, 62 (7):651-2 J. Clin. Pathol.en
dc.identifier.issn1472-4146-
dc.identifier.pmid19561235-
dc.identifier.doi10.1136/jcp.2008.061887-
dc.identifier.urihttp://hdl.handle.net/10541/85396-
dc.description.abstractHistopathologists in the current environment of medical negligence and litigation are more likely to use immunohistochemical investigations in their day-to-day practice to support their diagnosis and avoid future litigation. The caveat is that relying on immunohistochemistry is a double-edged sword and pathologists should be familiar with its limitations. We present a case of primary malignant peritoneal mesothelioma with an unusual immunohistochemical profile-desmin positive, EMA negative-and wish to highlight the importance of cautiously interpreting immunohistochemistry profiles when they do not fit the clinical history and histological appearance.en
dc.language.isoenen
dc.subjectPeritoneal Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshDesmin-
dc.subject.meshFatal Outcome-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMesothelioma-
dc.subject.meshMiddle Aged-
dc.subject.meshMucin-1-
dc.subject.meshPeritoneal Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleAn EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry?en
dc.typeArticleen
dc.contributor.departmentEast Lancashire Hospitals, UK. walidsalman@gmail.comen
dc.identifier.journalJournal of Clinical Pathologyen

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