To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.

2.50
Hdl Handle:
http://hdl.handle.net/10541/85220
Title:
To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.
Authors:
Shervington, Leroy A; Smith, Nigel K; Norman, Emma; Ward, Timothy H; Phillips, Roger M; Shervington, Amal
Abstract:
Four ester prodrugs derived from the bifunctional alkylating agent chlorambucil, and one of its nitro-derivatives, 3-nitrochlorambucil conjugated to prasterone and pregnenolone, were synthesized and tested for their cytotoxic activity against eight human cell lines, using the standard MTT assay. A comparison between the esters and the controls, namely chlorambucil and 3-nitrochlorambucil would suggest that all four esters possess to varying degrees, specificity towards the breast adenocarcinoma cell line (MDA-mb468) than the other seven cells' lines tested. The overall findings are encouraging since it infers that these lipophilic esters not only have the ability to traverse specific cell membranes but also exhibit cytotoxicity towards most of the cell lines tested.
Affiliation:
School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, Preston, UK. lashervington@uclan.ac.uk
Citation:
To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. 2009, 44 (7):2944-51 Eur J Med Chem
Journal:
European Journal of Medicinal Chemistry
Issue Date:
Jul-2009
URI:
http://hdl.handle.net/10541/85220
DOI:
10.1016/j.ejmech.2008.11.014
PubMed ID:
19121874
Type:
Article
Language:
en
ISSN:
1768-3254
Appears in Collections:
All Paterson Institute for Cancer Research; Clinical and Experimental Pharmacology Group

Full metadata record

DC FieldValue Language
dc.contributor.authorShervington, Leroy Aen
dc.contributor.authorSmith, Nigel Ken
dc.contributor.authorNorman, Emmaen
dc.contributor.authorWard, Timothy Hen
dc.contributor.authorPhillips, Roger Men
dc.contributor.authorShervington, Amalen
dc.date.accessioned2009-11-03T12:47:09Z-
dc.date.available2009-11-03T12:47:09Z-
dc.date.issued2009-07-
dc.identifier.citationTo determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. 2009, 44 (7):2944-51 Eur J Med Chemen
dc.identifier.issn1768-3254-
dc.identifier.pmid19121874-
dc.identifier.doi10.1016/j.ejmech.2008.11.014-
dc.identifier.urihttp://hdl.handle.net/10541/85220-
dc.description.abstractFour ester prodrugs derived from the bifunctional alkylating agent chlorambucil, and one of its nitro-derivatives, 3-nitrochlorambucil conjugated to prasterone and pregnenolone, were synthesized and tested for their cytotoxic activity against eight human cell lines, using the standard MTT assay. A comparison between the esters and the controls, namely chlorambucil and 3-nitrochlorambucil would suggest that all four esters possess to varying degrees, specificity towards the breast adenocarcinoma cell line (MDA-mb468) than the other seven cells' lines tested. The overall findings are encouraging since it infers that these lipophilic esters not only have the ability to traverse specific cell membranes but also exhibit cytotoxicity towards most of the cell lines tested.en
dc.language.isoenen
dc.subjectCell Line Tumouren
dc.subjectCanceren
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCell Line, Tumor-
dc.subject.meshChlorambucil-
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshDehydroepiandrosterone-
dc.subject.meshEsters-
dc.subject.meshHumans-
dc.subject.meshInhibitory Concentration 50-
dc.subject.meshNeoplasms-
dc.subject.meshNitro Compounds-
dc.subject.meshPregnenolone-
dc.titleTo determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.en
dc.typeArticleen
dc.contributor.departmentSchool of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, Preston, UK. lashervington@uclan.ac.uken
dc.identifier.journalEuropean Journal of Medicinal Chemistryen

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