Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84996
Title:
Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.
Authors:
Friedrich, Nele; Haring, Robin; Nauck, Matthias; Lüdemann, Jan; Rosskopf, Dieter; Spilcke-Liss, Elisabeth; Felix, Stephan B; Dörr, Marcus; Brabant, Georg E; Völzke, Henry; Wallaschofski, Henri
Abstract:
BACKGROUND: Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study. METHODS: From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles. RESULTS: Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)]. CONCLUSIONS: The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.
Affiliation:
Institute for Community Medicine, Ernst Moritz Arndt University, D-17487 Greifswald, Germany. nele.friedrich@uni-greifswald.de
Citation:
Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. 2009, 94 (5):1732-9 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
May-2009
URI:
http://hdl.handle.net/10541/84996
DOI:
10.1210/jc.2008-2138
PubMed ID:
19223521
Type:
Article
Language:
en
ISSN:
1945-7197
Appears in Collections:
All Christie Publications ; Endocrinology

Full metadata record

DC FieldValue Language
dc.contributor.authorFriedrich, Neleen
dc.contributor.authorHaring, Robinen
dc.contributor.authorNauck, Matthiasen
dc.contributor.authorLüdemann, Janen
dc.contributor.authorRosskopf, Dieteren
dc.contributor.authorSpilcke-Liss, Elisabethen
dc.contributor.authorFelix, Stephan Ben
dc.contributor.authorDörr, Marcusen
dc.contributor.authorBrabant, Georg Een
dc.contributor.authorVölzke, Henryen
dc.contributor.authorWallaschofski, Henrien
dc.date.accessioned2009-10-29T10:33:50Z-
dc.date.available2009-10-29T10:33:50Z-
dc.date.issued2009-05-
dc.identifier.citationMortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. 2009, 94 (5):1732-9 J. Clin. Endocrinol. Metab.en
dc.identifier.issn1945-7197-
dc.identifier.pmid19223521-
dc.identifier.doi10.1210/jc.2008-2138-
dc.identifier.urihttp://hdl.handle.net/10541/84996-
dc.description.abstractBACKGROUND: Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study. METHODS: From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles. RESULTS: Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)]. CONCLUSIONS: The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.en
dc.language.isoenen
dc.subjectCanceren
dc.subjectCancer Mortalityen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMortality-
dc.subject.meshNeoplasms-
dc.subject.meshProportional Hazards Models-
dc.subject.meshSocioeconomic Factors-
dc.subject.meshYoung Adult-
dc.titleMortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.en
dc.typeArticleen
dc.contributor.departmentInstitute for Community Medicine, Ernst Moritz Arndt University, D-17487 Greifswald, Germany. nele.friedrich@uni-greifswald.deen
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

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