2.50
Hdl Handle:
http://hdl.handle.net/10541/84454
Title:
Chromosomal radiosensitivity and low penetrance predisposition to cancer.
Authors:
Scott, David
Abstract:
This mini-review summarises studies in this Institute on the sensitivity of cells of patients with common cancers to the chromosome-damaging effects of ionising radiation, in the context of related studies. Using the 90th percentile of healthy controls (n >200) as the cut-off point between a normal and a sensitive response, 40% of patients with breast cancer (n = 166) were sensitive when cells were irradiated in the G2 phase of the cell cycle. Smaller studies showed that patients with colorectal, head and neck (at < 45 years) and childhood cancers also exhibited degrees of enhanced sensitivity, whereas cervical and lung cancer cases did not. Cells from breast and head and neck cases irradiated in G(0) also showed increased sensitivity. We propose that such elevated sensitivity is a marker of low penetrance predisposition to cancer. The strongest support for this hypothesis was our demonstration of the Mendelian heritability of chromosomal radiosensitivity in 95 family members of breast cancer cases. Challenges for the future include more heritability studies, identification of the underlying genetic determinants, assessment of the associated cancer risk (spontaneous and radiogenic) and population screening for cancer prevention strategies.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. david.scott2004@btinternet.com
Citation:
Chromosomal radiosensitivity and low penetrance predisposition to cancer. 2004, 104 (1-4):365-70 Cytogenet. Genome Res.
Journal:
Cytogenetic and Genome Research
Issue Date:
2004
URI:
http://hdl.handle.net/10541/84454
DOI:
10.1159/000077517
PubMed ID:
15162066
Language:
en
ISSN:
1424-859X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorScott, David-
dc.date.accessioned2009-10-19T15:55:46Z-
dc.date.available2009-10-19T15:55:46Z-
dc.date.issued2004-
dc.identifier.citationChromosomal radiosensitivity and low penetrance predisposition to cancer. 2004, 104 (1-4):365-70 Cytogenet. Genome Res.en
dc.identifier.issn1424-859X-
dc.identifier.pmid15162066-
dc.identifier.doi10.1159/000077517-
dc.identifier.urihttp://hdl.handle.net/10541/84454-
dc.description.abstractThis mini-review summarises studies in this Institute on the sensitivity of cells of patients with common cancers to the chromosome-damaging effects of ionising radiation, in the context of related studies. Using the 90th percentile of healthy controls (n >200) as the cut-off point between a normal and a sensitive response, 40% of patients with breast cancer (n = 166) were sensitive when cells were irradiated in the G2 phase of the cell cycle. Smaller studies showed that patients with colorectal, head and neck (at < 45 years) and childhood cancers also exhibited degrees of enhanced sensitivity, whereas cervical and lung cancer cases did not. Cells from breast and head and neck cases irradiated in G(0) also showed increased sensitivity. We propose that such elevated sensitivity is a marker of low penetrance predisposition to cancer. The strongest support for this hypothesis was our demonstration of the Mendelian heritability of chromosomal radiosensitivity in 95 family members of breast cancer cases. Challenges for the future include more heritability studies, identification of the underlying genetic determinants, assessment of the associated cancer risk (spontaneous and radiogenic) and population screening for cancer prevention strategies.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectColorectal Canceren
dc.subjectHead and Neck Canceren
dc.subjectCanceren
dc.subjectHereditary Cancer Syndromesen
dc.subjectCultured Tumour Cellsen
dc.subject.meshAdult-
dc.subject.meshAtaxia Telangiectasia-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma-
dc.subject.meshCell Cycle-
dc.subject.meshChild-
dc.subject.meshChromosomes, Human-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Repair-
dc.subject.meshFamily Health-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshNeoplastic Syndromes, Hereditary-
dc.subject.meshPenetrance-
dc.subject.meshRadiation Tolerance-
dc.subject.meshTumor Cells, Cultured-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleChromosomal radiosensitivity and low penetrance predisposition to cancer.en
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. david.scott2004@btinternet.comen
dc.identifier.journalCytogenetic and Genome Researchen

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