Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84335
Title:
Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer.
Authors:
Naganuma, Hiroshi; Kono, Koji; Mori, Yoshiyuki; Takayoshi, Sekikawa; Stern, Peter L; Tasaka, Kachio; Matsumoto, Yoshiro
Abstract:
BACKGROUND: Oncofetal antigen 5T4 is defined by a monoclonal antibody raised against placental trophoblast membranes. Antigen 5T4 is reported to be expressed only on trophoblasts and neoplastic cells and would be a potentially useful marker for neoplastic cells. MATERIALS AND METHODS: We evaluated the expression of 5T4 oncofetal antigen in gastric cancer by immunohistochemistry and investigated whether or not the expression of this antigen is correlated with the prognosis of patients with gastric cancer. RESULTS: The 5T4 antigen was detected in 51.6% of primary gastric cancer (n = 62) and 5T4-reactivity was more frequently observed in carcinoma with lymph node metastasis (p < 0.05). The overall survival of 5T4-positive patients was significantly worse than that of 5T4-negative patients, analyzed by the log-rank test (p < 0.05), although multivariate analysis indicated that 5T4 expression was not an independent prognostic factor. CONCLUSION: The assessment of 5T4 expression may be useful in identifying gastric cancer patients with a poor prognosis.
Citation:
Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer., 22 (2B):1033-8 Anticancer Res.
Journal:
Anticancer Research
Issue Date:
16-Oct-2009
URI:
http://hdl.handle.net/10541/84335
PubMed ID:
12168897
Type:
Article
Language:
en
ISSN:
0250-7005
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorNaganuma, Hiroshien
dc.contributor.authorKono, Kojien
dc.contributor.authorMori, Yoshiyukien
dc.contributor.authorTakayoshi, Sekikawaen
dc.contributor.authorStern, Peter Len
dc.contributor.authorTasaka, Kachioen
dc.contributor.authorMatsumoto, Yoshiroen
dc.date.accessioned2009-10-16T11:07:34Z-
dc.date.available2009-10-16T11:07:34Z-
dc.date.issued2009-10-16T11:07:34Z-
dc.identifier.citationOncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer., 22 (2B):1033-8 Anticancer Res.en
dc.identifier.issn0250-7005-
dc.identifier.pmid12168897-
dc.identifier.urihttp://hdl.handle.net/10541/84335-
dc.description.abstractBACKGROUND: Oncofetal antigen 5T4 is defined by a monoclonal antibody raised against placental trophoblast membranes. Antigen 5T4 is reported to be expressed only on trophoblasts and neoplastic cells and would be a potentially useful marker for neoplastic cells. MATERIALS AND METHODS: We evaluated the expression of 5T4 oncofetal antigen in gastric cancer by immunohistochemistry and investigated whether or not the expression of this antigen is correlated with the prognosis of patients with gastric cancer. RESULTS: The 5T4 antigen was detected in 51.6% of primary gastric cancer (n = 62) and 5T4-reactivity was more frequently observed in carcinoma with lymph node metastasis (p < 0.05). The overall survival of 5T4-positive patients was significantly worse than that of 5T4-negative patients, analyzed by the log-rank test (p < 0.05), although multivariate analysis indicated that 5T4 expression was not an independent prognostic factor. CONCLUSION: The assessment of 5T4 expression may be useful in identifying gastric cancer patients with a poor prognosis.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectStomach Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAged-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMembrane Glycoproteins-
dc.subject.meshMiddle Aged-
dc.subject.meshPrognosis-
dc.subject.meshStomach Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleOncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer.en
dc.typeArticleen
dc.identifier.journalAnticancer Researchen

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