The effect of radiotherapy treatment changes on sites of relapse in stage I testicular seminoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84133
Title:
The effect of radiotherapy treatment changes on sites of relapse in stage I testicular seminoma.
Authors:
Taylor, Malcolm B; Carrington, Bernadette M; Livsey, Jacqueline E; Logue, John P
Abstract:
AIM: To evaluate relapse patterns in stage I testicular seminoma related to changes in radiotherapy practice.METHOD: Four hundred and six patients with stage I testicular seminoma were treated with adjuvant radiotherapy following orchidectomy: 338 patients received para-aortic radiotherapy only and 68 patients with added risk factors had radiotherapy extended to include the pelvis. Computed tomograms of relapsed patients were reviewed and sites of relapse were documented with correlation to the radiotherapy field. RESULTS: Thirteen relapses were identified; 10 occurring in the para-aortic radiotherapy group (3.0% relapse rate) and three in the extended radiotherapy field group (4.4% relapse rate). Sites of relapse were; five pelvis, three mediastinum, one lung, one scapula, one scrotum, while one patient had multiple relapse sites including the pelvis and one had a tumour marker relapse with no site identified. All the pelvic relapses occurred in the para-aortic radiotherapy group. CONCLUSION: Pelvic relapse only occurred when radiotherapy had been confined to the para-aortic region. Since para-aortic radiotherapy achieves equivalent outcome to wider field radiotherapy with reduced toxicity, it is likely to become standard practice in stage I seminoma and pelvic relapses will therefore increase in frequency. It is therefore important to include pelvic imaging when relapse is suspected.
Affiliation:
Department of Radiology, Christie Hospital NHS Trust, Wilmington, Manchester, UK.
Citation:
The effect of radiotherapy treatment changes on sites of relapse in stage I testicular seminoma. 2001, 56 (2):116-9notClin Radiol
Journal:
Clinical Radiology
Issue Date:
Feb-2001
URI:
http://hdl.handle.net/10541/84133
DOI:
10.1053/crad.2000.0644
PubMed ID:
11222068
Type:
Article
Language:
en
ISSN:
0009-9260
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorTaylor, Malcolm Ben
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorLivsey, Jacqueline Een
dc.contributor.authorLogue, John Pen
dc.date.accessioned2009-10-13T08:27:01Z-
dc.date.available2009-10-13T08:27:01Z-
dc.date.issued2001-02-
dc.identifier.citationThe effect of radiotherapy treatment changes on sites of relapse in stage I testicular seminoma. 2001, 56 (2):116-9notClin Radiolen
dc.identifier.issn0009-9260-
dc.identifier.pmid11222068-
dc.identifier.doi10.1053/crad.2000.0644-
dc.identifier.urihttp://hdl.handle.net/10541/84133-
dc.description.abstractAIM: To evaluate relapse patterns in stage I testicular seminoma related to changes in radiotherapy practice.METHOD: Four hundred and six patients with stage I testicular seminoma were treated with adjuvant radiotherapy following orchidectomy: 338 patients received para-aortic radiotherapy only and 68 patients with added risk factors had radiotherapy extended to include the pelvis. Computed tomograms of relapsed patients were reviewed and sites of relapse were documented with correlation to the radiotherapy field. RESULTS: Thirteen relapses were identified; 10 occurring in the para-aortic radiotherapy group (3.0% relapse rate) and three in the extended radiotherapy field group (4.4% relapse rate). Sites of relapse were; five pelvis, three mediastinum, one lung, one scapula, one scrotum, while one patient had multiple relapse sites including the pelvis and one had a tumour marker relapse with no site identified. All the pelvic relapses occurred in the para-aortic radiotherapy group. CONCLUSION: Pelvic relapse only occurred when radiotherapy had been confined to the para-aortic region. Since para-aortic radiotherapy achieves equivalent outcome to wider field radiotherapy with reduced toxicity, it is likely to become standard practice in stage I seminoma and pelvic relapses will therefore increase in frequency. It is therefore important to include pelvic imaging when relapse is suspected.en
dc.language.isoenen
dc.subjectCancer Stagingen
dc.subjectTesticular Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Staging-
dc.subject.meshOrchiectomy-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshSeminoma-
dc.subject.meshTesticular Neoplasms-
dc.subject.meshTomography, X-Ray Computed-
dc.titleThe effect of radiotherapy treatment changes on sites of relapse in stage I testicular seminoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiology, Christie Hospital NHS Trust, Wilmington, Manchester, UK.en
dc.identifier.journalClinical Radiologyen

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