Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84079
Title:
Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature.
Authors:
Menasce, Lia P; Shanks, Jonathan H; Banerjee, Saumitra S; Harris, Martin
Abstract:
AIMS: To bring to wider attention this uncommon, poorly understood entity which may closely resemble, clinically and morphologically, follicular lymphoma. METHODS AND RESULTS: We report three cases of follicular lymphoid hyperplasia of the hard palate and oral mucosa which caused diagnostic difficulties for the referring pathologists. The clinicopathological features are described and integrated into a review of the 16 previously recorded cases. The condition most commonly presents as a slowly growing mass situated in the posterior hard palate but may present with multicentric oral lesions and lymphadenopathy. Morphologically, it is characterized by a dense follicular lymphoid infiltrate within the lamina propria which may show the classical features of benign reactive hyperplasia, but not uncommonly, indistinct germinal centres, ill-defined mantles and a lack of tingible-body macrophages are features which may lead to an erroneous diagnosis of follicular lymphoma. CONCLUSIONS: Follicular lymphoid hyperplasia of the palate is a poorly recognized entity which is frequently confused with follicular lymphoma. Awareness of the entity combined with the use of immunohistochemistry for immunoglobulin light chains and bcl-2 protein allows a correct diagnosis to be made avoiding extensive investigation and aggressive treatment to the patient.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature. 2001, 39 (4):353-8 Histopathology
Journal:
Histopathology
Issue Date:
Oct-2001
URI:
http://hdl.handle.net/10541/84079
PubMed ID:
11683934
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorShanks, Jonathan Hen
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2009-10-12T16:00:32Z-
dc.date.available2009-10-12T16:00:32Z-
dc.date.issued2001-10-
dc.identifier.citationFollicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature. 2001, 39 (4):353-8 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid11683934-
dc.identifier.urihttp://hdl.handle.net/10541/84079-
dc.description.abstractAIMS: To bring to wider attention this uncommon, poorly understood entity which may closely resemble, clinically and morphologically, follicular lymphoma. METHODS AND RESULTS: We report three cases of follicular lymphoid hyperplasia of the hard palate and oral mucosa which caused diagnostic difficulties for the referring pathologists. The clinicopathological features are described and integrated into a review of the 16 previously recorded cases. The condition most commonly presents as a slowly growing mass situated in the posterior hard palate but may present with multicentric oral lesions and lymphadenopathy. Morphologically, it is characterized by a dense follicular lymphoid infiltrate within the lamina propria which may show the classical features of benign reactive hyperplasia, but not uncommonly, indistinct germinal centres, ill-defined mantles and a lack of tingible-body macrophages are features which may lead to an erroneous diagnosis of follicular lymphoma. CONCLUSIONS: Follicular lymphoid hyperplasia of the palate is a poorly recognized entity which is frequently confused with follicular lymphoma. Awareness of the entity combined with the use of immunohistochemistry for immunoglobulin light chains and bcl-2 protein allows a correct diagnosis to be made avoiding extensive investigation and aggressive treatment to the patient.en
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHyperplasia-
dc.subject.meshImmunoglobulin kappa-Chains-
dc.subject.meshImmunoglobulin lambda-Chains-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymphoid Tissue-
dc.subject.meshLymphoma, Follicular-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMouth Mucosa-
dc.subject.meshPalate-
dc.subject.meshProto-Oncogene Proteins c-bcl-2-
dc.titleFollicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen

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