Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84077
Title:
Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues.
Authors:
McNally, Richard J Q; Cairns, Donal P; Eden, Tim O B; Kelsey, Anna M; Taylor, G Malcolm; Birch, Jillian M
Abstract:
The age-sex distributions and temporal trends in incidence of leukaemia and lymphoma from the Manchester Children's Tumour Registry (MCTR), 1954-1998, are reported. This 45-year study includes 1795 children, all of whom had a histologically and/or cytologically verified leukaemia or lymphoma. At the time of their diagnoses all the children were under 15 years of age and were resident in a geographically defined area of northwest England covered by the MCTR. Log-linear modelling identified significant linear increases in acute lymphoblastic leukaemia (ALL) (average annual increase 0.7%; P= 0.005) and in Hodgkin's disease (HD) (1.2%, P=0.04), but not in acute myeloid leukaemia (AML), nor in non-Hodgkin's lymphoma (NHL). The increase in ALL was most pronounced amongst males, aged 1-4 years, and is likely to be due to precursor B-cell leukaemias. The increases in ALL and HD are discussed in relation to current hypotheses suggesting a role for infection. Additionally, a non-linear cohort effect was identified for NHL (P= 0.008), which may indicate the involvement of environmental factors other than infection.
Affiliation:
Cancer Research Campaign Paediatric and Familial Cancer Research Group, University of Manchester, UK.
Citation:
Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues. 2001, 15 (10):1612-8 Leukemia
Journal:
Leukemia
Issue Date:
Oct-2001
URI:
http://hdl.handle.net/10541/84077
PubMed ID:
11587220
Type:
Article
Language:
en
ISSN:
0887-6924
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMcNally, Richard J Qen
dc.contributor.authorCairns, Donal Pen
dc.contributor.authorEden, Tim O Ben
dc.contributor.authorKelsey, Anna Men
dc.contributor.authorTaylor, G Malcolmen
dc.contributor.authorBirch, Jillian Men
dc.date.accessioned2009-10-12T15:49:09Z-
dc.date.available2009-10-12T15:49:09Z-
dc.date.issued2001-10-
dc.identifier.citationExamination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues. 2001, 15 (10):1612-8 Leukemiaen
dc.identifier.issn0887-6924-
dc.identifier.pmid11587220-
dc.identifier.urihttp://hdl.handle.net/10541/84077-
dc.description.abstractThe age-sex distributions and temporal trends in incidence of leukaemia and lymphoma from the Manchester Children's Tumour Registry (MCTR), 1954-1998, are reported. This 45-year study includes 1795 children, all of whom had a histologically and/or cytologically verified leukaemia or lymphoma. At the time of their diagnoses all the children were under 15 years of age and were resident in a geographically defined area of northwest England covered by the MCTR. Log-linear modelling identified significant linear increases in acute lymphoblastic leukaemia (ALL) (average annual increase 0.7%; P= 0.005) and in Hodgkin's disease (HD) (1.2%, P=0.04), but not in acute myeloid leukaemia (AML), nor in non-Hodgkin's lymphoma (NHL). The increase in ALL was most pronounced amongst males, aged 1-4 years, and is likely to be due to precursor B-cell leukaemias. The increases in ALL and HD are discussed in relation to current hypotheses suggesting a role for infection. Additionally, a non-linear cohort effect was identified for NHL (P= 0.008), which may indicate the involvement of environmental factors other than infection.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subjectMyeloid Leukaemiaen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAcute Disease-
dc.subject.meshAdolescent-
dc.subject.meshAge Factors-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEngland-
dc.subject.meshEpidemiologic Measurements-
dc.subject.meshFemale-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshLeukemia-
dc.subject.meshLeukemia, Myeloid-
dc.subject.meshLymphoma-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMale-
dc.subject.meshModels, Statistical-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshRegistries-
dc.subject.meshSex Factors-
dc.titleExamination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Paediatric and Familial Cancer Research Group, University of Manchester, UK.en
dc.identifier.journalLeukemiaen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.