Patterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84073
Title:
Patterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up.
Authors:
Livsey, Jacqueline E; Taylor, Benjamin; Mobarek, Nabil; Cooper, Rachel A; Carrington, Bernadette M; Logue, John P
Abstract:
A retrospective review was undertaken of 409 consecutive patients treated with adjuvant radiotherapy for Stage I seminoma between 1988 and 1997. A total of 339 men were treated to a volume encompassing the para-aortic nodes and 70 were treated with extended field radiotherapy. The patients were followed up within oncology clinics adhering to a standard protocol of clinical examination, chest radiography and measurement of serum marker levels. No routine computed tomographic (CT) scans were carried out. At a median follow-up of 57 months, 13 patients have relapsed, giving a recurrence-free rate of 97.2% at 3 years and 96.8% at 5 years. Of these, eight (62%) were detected at routine appointments and five (38%) requested early appointments. Chest radiography (2/5) and serum marker levels (3/5) identified disease in asymptomatic patients. Eight patients (62%) had raised markers at relapse, including two with normal serum markers at original presentation. The median size of pelvic node recurrences in the para-aortic-treated group was 7.3 cm (2.8-13 cm). Four patients have developed second testicular primaries: three were detected at routine appointments and one patient had requested an early appointment. We conclude that regular follow-up with serum marker estimations and chest radiography is sufficient to detect recurrence at an early stage and that our policy of no routine CT scanning has been shown to give acceptable results.
Affiliation:
Department of Clinical Oncology, Christie Hospital, Manchester, UK.
Citation:
Patterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up. 2001, 13 (4):296-300 Clin Oncol
Journal:
Clinical Oncology
Issue Date:
2001
URI:
http://hdl.handle.net/10541/84073
PubMed ID:
11554630
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLivsey, Jacqueline Een
dc.contributor.authorTaylor, Benjaminen
dc.contributor.authorMobarek, Nabilen
dc.contributor.authorCooper, Rachel Aen
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorLogue, John Pen
dc.date.accessioned2009-10-12T15:35:30Z-
dc.date.available2009-10-12T15:35:30Z-
dc.date.issued2001-
dc.identifier.citationPatterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up. 2001, 13 (4):296-300 Clin Oncolen
dc.identifier.issn0936-6555-
dc.identifier.pmid11554630-
dc.identifier.urihttp://hdl.handle.net/10541/84073-
dc.description.abstractA retrospective review was undertaken of 409 consecutive patients treated with adjuvant radiotherapy for Stage I seminoma between 1988 and 1997. A total of 339 men were treated to a volume encompassing the para-aortic nodes and 70 were treated with extended field radiotherapy. The patients were followed up within oncology clinics adhering to a standard protocol of clinical examination, chest radiography and measurement of serum marker levels. No routine computed tomographic (CT) scans were carried out. At a median follow-up of 57 months, 13 patients have relapsed, giving a recurrence-free rate of 97.2% at 3 years and 96.8% at 5 years. Of these, eight (62%) were detected at routine appointments and five (38%) requested early appointments. Chest radiography (2/5) and serum marker levels (3/5) identified disease in asymptomatic patients. Eight patients (62%) had raised markers at relapse, including two with normal serum markers at original presentation. The median size of pelvic node recurrences in the para-aortic-treated group was 7.3 cm (2.8-13 cm). Four patients have developed second testicular primaries: three were detected at routine appointments and one patient had requested an early appointment. We conclude that regular follow-up with serum marker estimations and chest radiography is sufficient to detect recurrence at an early stage and that our policy of no routine CT scanning has been shown to give acceptable results.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectTesticular Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshDisease-Free Survival-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshRetrospective Studies-
dc.subject.meshSeminoma-
dc.subject.meshSurvival Rate-
dc.subject.meshTesticular Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titlePatterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalClinical Oncologyen

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