The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.
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Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94115, USA.Issue Date
2002-09
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Expression of the Kaposi's sarcoma-associated herpesvirus (KSHV) cyclin D homolog, K cyclin, is thought to contribute to viral oncogenesis. We show that K cyclin expression in primary cells sensitizes to apoptosis and induces growth arrest, both of which are dependent on p53 but independent of E2F1 or p19(ARF). DNA synthesis, but not cytokinesis, continues in K cyclin-expressing cells, leading to multinucleation and polyploidy. Such polyploid cells exhibit pronounced centrosome amplification and consequent aneuploidy. Our data suggest that K cyclin expression leads to cytokinesis defects and polyploidy, which activates p53. However, in the absence of p53, such cells survive and expand as an aneuploid population. Corroborating these findings, in vivo Emu; K cyclin expression cooperates with p53 loss in the induction of lymphomas.Citation
The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. 2002, 2 (3):229-41 Cancer CellJournal
Cancer CellDOI
http://dx.doi.org/10.1016/S1535-6108(02)00123-XPubMed ID
12242155Type
ArticleLanguage
enISSN
1535-6108ae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.1016/S1535-6108(02)00123-X
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