The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84045
Title:
The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.
Authors:
Verschuren, Emmy W; Klefstrom, Juha; Evan, Gerard I; Jones, Nic
Abstract:
Expression of the Kaposi's sarcoma-associated herpesvirus (KSHV) cyclin D homolog, K cyclin, is thought to contribute to viral oncogenesis. We show that K cyclin expression in primary cells sensitizes to apoptosis and induces growth arrest, both of which are dependent on p53 but independent of E2F1 or p19(ARF). DNA synthesis, but not cytokinesis, continues in K cyclin-expressing cells, leading to multinucleation and polyploidy. Such polyploid cells exhibit pronounced centrosome amplification and consequent aneuploidy. Our data suggest that K cyclin expression leads to cytokinesis defects and polyploidy, which activates p53. However, in the absence of p53, such cells survive and expand as an aneuploid population. Corroborating these findings, in vivo Emu; K cyclin expression cooperates with p53 loss in the induction of lymphomas.
Affiliation:
Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94115, USA.
Citation:
The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. 2002, 2 (3):229-41 Cancer Cell
Journal:
Cancer Cell
Issue Date:
Sep-2002
URI:
http://hdl.handle.net/10541/84045
DOI:
http://dx.doi.org/10.1016/S1535-6108(02)00123-X
PubMed ID:
12242155
Type:
Article
Language:
en
ISSN:
1535-6108
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorVerschuren, Emmy Wen
dc.contributor.authorKlefstrom, Juhaen
dc.contributor.authorEvan, Gerard Ien
dc.contributor.authorJones, Nicen
dc.date.accessioned2009-10-12T12:16:45Z-
dc.date.available2009-10-12T12:16:45Z-
dc.date.issued2002-09-
dc.identifier.citationThe oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. 2002, 2 (3):229-41 Cancer Cellen
dc.identifier.issn1535-6108-
dc.identifier.pmid12242155-
dc.identifier.doihttp://dx.doi.org/10.1016/S1535-6108(02)00123-X-
dc.identifier.urihttp://hdl.handle.net/10541/84045-
dc.description.abstractExpression of the Kaposi's sarcoma-associated herpesvirus (KSHV) cyclin D homolog, K cyclin, is thought to contribute to viral oncogenesis. We show that K cyclin expression in primary cells sensitizes to apoptosis and induces growth arrest, both of which are dependent on p53 but independent of E2F1 or p19(ARF). DNA synthesis, but not cytokinesis, continues in K cyclin-expressing cells, leading to multinucleation and polyploidy. Such polyploid cells exhibit pronounced centrosome amplification and consequent aneuploidy. Our data suggest that K cyclin expression leads to cytokinesis defects and polyploidy, which activates p53. However, in the absence of p53, such cells survive and expand as an aneuploid population. Corroborating these findings, in vivo Emu; K cyclin expression cooperates with p53 loss in the induction of lymphomas.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshCell Division-
dc.subject.meshCells, Cultured-
dc.subject.meshCentrosome-
dc.subject.meshCyclins-
dc.subject.meshEmbryo, Mammalian-
dc.subject.meshFibroblasts-
dc.subject.meshGenes, p53-
dc.subject.meshHerpesvirus 8, Human-
dc.subject.meshHumans-
dc.subject.meshLymphoma-
dc.subject.meshMice-
dc.subject.meshMice, Transgenic-
dc.subject.meshPolyploidy-
dc.subject.meshSarcoma, Kaposi-
dc.subject.meshTransduction, Genetic-
dc.titleThe oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.en
dc.typeArticleen
dc.contributor.departmentCancer Research Institute, University of California, San Francisco, San Francisco, CA 94115, USA.en
dc.identifier.journalCancer Cellen

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