A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa.

2.50
Hdl Handle:
http://hdl.handle.net/10541/84035
Title:
A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa.
Authors:
Barthel, D; Meineke, F A; Potten, Christopher S; Loeffler, M
Abstract:
A novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell flow, and turnover time. Results for the ventral tongue mucosa in a group of 55 BDF1 mice that were labelled at the same time of the day and culled at different time points within a 24-h period have been analysed. The results show a strong circadian rhythm in the migration velocity and the related parameters.
Affiliation:
University of Leipzig, Institute of Medical Informatics, Statistics & Epidemiology, Liebigstrasse 27, Leipzig D-04103, Germany.
Citation:
A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa. 2002, 35 Suppl 1:48-59 Cell Prolif.
Journal:
Cell Proliferation
Issue Date:
Aug-2002
URI:
http://hdl.handle.net/10541/84035
DOI:
http://dx.doi.org/10.1046/j.1365-2184.35.s1.5.x
PubMed ID:
12139707
Type:
Article
Language:
en
ISSN:
0960-7722
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBarthel, Den
dc.contributor.authorMeineke, F Aen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorLoeffler, Men
dc.date.accessioned2009-10-12T11:42:10Z-
dc.date.available2009-10-12T11:42:10Z-
dc.date.issued2002-08-
dc.identifier.citationA continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa. 2002, 35 Suppl 1:48-59 Cell Prolif.en
dc.identifier.issn0960-7722-
dc.identifier.pmid12139707-
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2184.35.s1.5.x-
dc.identifier.urihttp://hdl.handle.net/10541/84035-
dc.description.abstractA novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell flow, and turnover time. Results for the ventral tongue mucosa in a group of 55 BDF1 mice that were labelled at the same time of the day and culled at different time points within a 24-h period have been analysed. The results show a strong circadian rhythm in the migration velocity and the related parameters.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Count-
dc.subject.meshCell Movement-
dc.subject.meshCircadian Rhythm-
dc.subject.meshCytological Techniques-
dc.subject.meshEpithelial Cells-
dc.subject.meshMice-
dc.subject.meshModels, Biological-
dc.subject.meshMouth Mucosa-
dc.subject.meshThymidine-
dc.subject.meshTongue-
dc.subject.meshTritium-
dc.titleA continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa.en
dc.typeArticleen
dc.contributor.departmentUniversity of Leipzig, Institute of Medical Informatics, Statistics & Epidemiology, Liebigstrasse 27, Leipzig D-04103, Germany.en
dc.identifier.journalCell Proliferationen
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.