The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/83349
Title:
The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis.
Authors:
Anderson, Elizabeth
Abstract:
A relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERalpha) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERalpha expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERalpha and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.
Affiliation:
Tumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK. eanderson@picr.man.ac.uk
Citation:
The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. 2002, 4 (5):197-201 Breast Cancer Res.
Journal:
Breast Cancer Research
Issue Date:
2002
URI:
http://hdl.handle.net/10541/83349
DOI:
10.1186/bcr452
PubMed ID:
12223124
Type:
Article
Language:
en
ISSN:
1465-5411
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorAnderson, Elizabeth-
dc.date.accessioned2009-10-02T15:41:34Z-
dc.date.available2009-10-02T15:41:34Z-
dc.date.issued2002-
dc.identifier.citationThe role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. 2002, 4 (5):197-201 Breast Cancer Res.en
dc.identifier.issn1465-5411-
dc.identifier.pmid12223124-
dc.identifier.doi10.1186/bcr452-
dc.identifier.urihttp://hdl.handle.net/10541/83349-
dc.description.abstractA relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERalpha) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERalpha expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERalpha and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectOestrogen Receptorsen
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshEpithelial Cells-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshReceptors, Estrogen-
dc.subject.meshReceptors, Progesterone-
dc.subject.meshSignal Transduction-
dc.titleThe role of oestrogen and progesterone receptors in human mammary development and tumorigenesis.en
dc.typeArticleen
dc.contributor.departmentTumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK. eanderson@picr.man.ac.uken
dc.identifier.journalBreast Cancer Researchen
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