Achieving pregnancy against the odds: successful implantation of frozen-thawed embryos generated by ICSI using spermatozoa banked prior to chemo/radiotherapy for Hodgkin's disease and acute leukaemia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/83234
Title:
Achieving pregnancy against the odds: successful implantation of frozen-thawed embryos generated by ICSI using spermatozoa banked prior to chemo/radiotherapy for Hodgkin's disease and acute leukaemia.
Authors:
Horne, G; Atkinson, A D; Brison, Daniel R; Radford, John A ( 0000-0001-7898-2786 ) ; Yin, J A; Edi-Osagie, E C; Pease, E H E; Lieberman, B A
Abstract:
Two cases are reported of successful pregnancies following long-term semen banking prior to chemotherapy and radiotherapy for malignancy. With the first case, the patient banked semen at the age of 20 years prior to chemotherapy for Hodgkin's disease; 11 years later the thawed semen was used for IVF with intracytoplasmic sperm injection (ICSI), resulting in twins being born following the transfer of frozen-thawed embryos. In the second case, the patient banked semen at the age of 17 years prior to chemotherapy and radiotherapy for acute myeloid leukaemia; 8 years later it was used for ICSI, resulting in triplets being born following the transfer of frozen-thawed embryos. These cases support long-term semen banking for men whose future fertility may be compromised by suppression of spermatogenesis secondary to administration of chemo/radiotherapy treatment. The advent of successful ICSI combined with embryo cryopreservation has increased the chance of thawed cryopreserved semen achieving fertilization. Banking of a single ejaculate prior to commencement of chemotherapy/radiotherapy treatment may preserve potential fertility without compromising the oncology treatment.
Affiliation:
Department of Reproductive Medicine, St Mary's Hospital, Manchester M13 0JH, UK. greg.smh1.cmht.nwest.nhs.uk
Citation:
Achieving pregnancy against the odds: successful implantation of frozen-thawed embryos generated by ICSI using spermatozoa banked prior to chemo/radiotherapy for Hodgkin's disease and acute leukaemia. 2001, 16 (1):107-109 Hum. Reprod.
Journal:
Human Reproduction
Issue Date:
Jan-2001
URI:
http://hdl.handle.net/10541/83234
PubMed ID:
11139546
Type:
Article
Language:
en
ISSN:
0268-1161
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHorne, G-
dc.contributor.authorAtkinson, A D-
dc.contributor.authorBrison, Daniel R-
dc.contributor.authorRadford, John A-
dc.contributor.authorYin, J A-
dc.contributor.authorEdi-Osagie, E C-
dc.contributor.authorPease, E H E-
dc.contributor.authorLieberman, B A-
dc.date.accessioned2009-10-01T13:45:08Z-
dc.date.available2009-10-01T13:45:08Z-
dc.date.issued2001-01-
dc.identifier.citationAchieving pregnancy against the odds: successful implantation of frozen-thawed embryos generated by ICSI using spermatozoa banked prior to chemo/radiotherapy for Hodgkin's disease and acute leukaemia. 2001, 16 (1):107-109 Hum. Reprod.en
dc.identifier.issn0268-1161-
dc.identifier.pmid11139546-
dc.identifier.urihttp://hdl.handle.net/10541/83234-
dc.description.abstractTwo cases are reported of successful pregnancies following long-term semen banking prior to chemotherapy and radiotherapy for malignancy. With the first case, the patient banked semen at the age of 20 years prior to chemotherapy for Hodgkin's disease; 11 years later the thawed semen was used for IVF with intracytoplasmic sperm injection (ICSI), resulting in twins being born following the transfer of frozen-thawed embryos. In the second case, the patient banked semen at the age of 17 years prior to chemotherapy and radiotherapy for acute myeloid leukaemia; 8 years later it was used for ICSI, resulting in triplets being born following the transfer of frozen-thawed embryos. These cases support long-term semen banking for men whose future fertility may be compromised by suppression of spermatogenesis secondary to administration of chemo/radiotherapy treatment. The advent of successful ICSI combined with embryo cryopreservation has increased the chance of thawed cryopreserved semen achieving fertilization. Banking of a single ejaculate prior to commencement of chemotherapy/radiotherapy treatment may preserve potential fertility without compromising the oncology treatment.en
dc.language.isoenen
dc.subjectAcute Myeloid Leukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCryopreservation-
dc.subject.meshFemale-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Myeloid, Acute-
dc.subject.meshMale-
dc.subject.meshOligospermia-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Outcome-
dc.subject.meshSemen Preservation-
dc.subject.meshSperm Injections, Intracytoplasmic-
dc.subject.meshSpermatogenesis-
dc.titleAchieving pregnancy against the odds: successful implantation of frozen-thawed embryos generated by ICSI using spermatozoa banked prior to chemo/radiotherapy for Hodgkin's disease and acute leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Reproductive Medicine, St Mary's Hospital, Manchester M13 0JH, UK. greg.smh1.cmht.nwest.nhs.uken
dc.identifier.journalHuman Reproductionen

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