Monotypic angiomyolipoma of the nasal cavity: a heretofore undescribed occurrence.

2.50
Hdl Handle:
http://hdl.handle.net/10541/82515
Title:
Monotypic angiomyolipoma of the nasal cavity: a heretofore undescribed occurrence.
Authors:
Banerjee, Saumitra S; Eyden, Brian P; Trenholm, P W; Sheikh, M Y; Wakamatsu, K; Ancans, J; Rosai, J
Abstract:
A monotypic angiomyolipoma of the nasal cavity in a 34-year-old woman is described. Tumor cells were spindled or epithelioid and contained glycogen and diastase-resistant PAS-positive granules. There were few mitoses, and necrosis was absent, indicating a benign tumor. The stroma was markedly vascular, and a few adipocytes were seen in one area. Cells were positive for melanocyte and muscle markers. Electron microscopy revealed abundant dense granules. Although melanin was absent histochemically, it was present using a chemical assay, and the granules may, therefore, be atypical melanosomes. Fine actin filaments, attachment plaques and lamina were present. Initial assessment of the lesion indicated malignant melanoma, but the immunostaining and histologic features indicated monotypic angiomyolipoma. To the best of our knowledge, this is the first such case in the nasal cavity.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Monotypic angiomyolipoma of the nasal cavity: a heretofore undescribed occurrence. 2001, 9 (4):309-15 Int. J. Surg. Pathol.
Journal:
International Journal of Surgical Pathology
Issue Date:
Oct-2001
URI:
http://hdl.handle.net/10541/82515
DOI:
10.1177/106689690100900410
PubMed ID:
12574849
Type:
Article
Language:
en
ISSN:
1066-8969
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBanerjee, Saumitra S-
dc.contributor.authorEyden, Brian P-
dc.contributor.authorTrenholm, P W-
dc.contributor.authorSheikh, M Y-
dc.contributor.authorWakamatsu, K-
dc.contributor.authorAncans, J-
dc.contributor.authorRosai, J-
dc.date.accessioned2009-09-24T12:28:02Z-
dc.date.available2009-09-24T12:28:02Z-
dc.date.issued2001-10-
dc.identifier.citationMonotypic angiomyolipoma of the nasal cavity: a heretofore undescribed occurrence. 2001, 9 (4):309-15 Int. J. Surg. Pathol.en
dc.identifier.issn1066-8969-
dc.identifier.pmid12574849-
dc.identifier.doi10.1177/106689690100900410-
dc.identifier.urihttp://hdl.handle.net/10541/82515-
dc.description.abstractA monotypic angiomyolipoma of the nasal cavity in a 34-year-old woman is described. Tumor cells were spindled or epithelioid and contained glycogen and diastase-resistant PAS-positive granules. There were few mitoses, and necrosis was absent, indicating a benign tumor. The stroma was markedly vascular, and a few adipocytes were seen in one area. Cells were positive for melanocyte and muscle markers. Electron microscopy revealed abundant dense granules. Although melanin was absent histochemically, it was present using a chemical assay, and the granules may, therefore, be atypical melanosomes. Fine actin filaments, attachment plaques and lamina were present. Initial assessment of the lesion indicated malignant melanoma, but the immunostaining and histologic features indicated monotypic angiomyolipoma. To the best of our knowledge, this is the first such case in the nasal cavity.en
dc.language.isoenen
dc.subjectNose Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshActins-
dc.subject.meshAdipocytes-
dc.subject.meshAdult-
dc.subject.meshAngiomyolipoma-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshEpithelioid Cells-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshInclusion Bodies-
dc.subject.meshMelanins-
dc.subject.meshMelanoma-
dc.subject.meshNasal Cavity-
dc.subject.meshNose Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleMonotypic angiomyolipoma of the nasal cavity: a heretofore undescribed occurrence.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalInternational Journal of Surgical Pathologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.