Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.

2.50
Hdl Handle:
http://hdl.handle.net/10541/82466
Title:
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.
Authors:
Lees, Nicholas P; Harrison, Kathryn L; Hill, Elizabeth; Hall, C Nicholas; Margison, Geoffrey P; Povey, Andrew C
Abstract:
In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
Affiliation:
Cancer Research UK, Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.
Citation:
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. 2002, 87 (2):168-70 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
15-Jul-2002
URI:
http://hdl.handle.net/10541/82466
DOI:
10.1038/sj.bjc.6600455
PubMed ID:
12107837
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLees, Nicholas P-
dc.contributor.authorHarrison, Kathryn L-
dc.contributor.authorHill, Elizabeth-
dc.contributor.authorHall, C Nicholas-
dc.contributor.authorMargison, Geoffrey P-
dc.contributor.authorPovey, Andrew C-
dc.date.accessioned2009-09-24T10:20:38Z-
dc.date.available2009-09-24T10:20:38Z-
dc.date.issued2002-07-15-
dc.identifier.citationLongitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. 2002, 87 (2):168-70 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid12107837-
dc.identifier.doi10.1038/sj.bjc.6600455-
dc.identifier.urihttp://hdl.handle.net/10541/82466-
dc.description.abstractIn a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.en
dc.language.isoenen
dc.subjectCecal Canceren
dc.subjectCancer Proteinsen
dc.subjectRectal Canceren
dc.subjectSigmoid Canceren
dc.subject.meshAdenocarcinoma-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlkylating Agents-
dc.subject.meshCecal Neoplasms-
dc.subject.meshColon-
dc.subject.meshFemale-
dc.subject.meshGenetic Variation-
dc.subject.meshHumans-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase-
dc.subject.meshRectal Neoplasms-
dc.subject.meshRectum-
dc.subject.meshSigmoid Neoplasms-
dc.titleLongitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK, Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.en
dc.identifier.journalBritish Journal of Canceren
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