Characterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus).

2.50
Hdl Handle:
http://hdl.handle.net/10541/82462
Title:
Characterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus).
Authors:
Jenson, Hal B; Ench, Yasmin; Zhang, Yanjin; Gao, Shou-Jiang; Arrand, John R; Mackett, Mike
Abstract:
A gammaherpesvirus related to Epstein-Barr virus (EBV; Human herpesvirus 4) infects otherwise healthy common marmosets (Callithrix jacchus). Long-term culture of common marmoset peripheral blood lymphocytes resulted in outgrowth of spontaneously immortalized lymphoblastoid cell lines, primarily of B cell lineage. Electron microscopy of cells and supernatants showed herpesvirus particles. There were high rates of serological cross-reactivity to other herpesviruses (68-86%), but with very low geometric mean antibody titres [1:12 to human herpesvirus 6 and 1:14 to Herpesvirus papio (Cercopithecine herpesvirus 12)]. Sequence analysis of the conserved herpesvirus DNA polymerase gene showed that the virus is a member of the lymphocryptovirus subgroup and is most closely related to a lymphocryptovirus from rhesus macaques and is closely related to EBV and Herpesvirus papio. High seroprevalence (79%, with geometric mean antibody titre of 1:110) among 28 common marmosets from two geographically distinct colonies indicated that the virus is likely present in many common marmosets in captivity. A New World primate harbouring a lymphocryptovirus suggests that this subgroup arose much earlier than previously thought.
Affiliation:
Department of Pediatrics, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. jenson@uthscsa.edu
Citation:
Characterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus). 2002, 83 (Pt 7):1621-33 J. Gen. Virol.
Journal:
The Journal of General Virology
Issue Date:
Jul-2002
URI:
http://hdl.handle.net/10541/82462
PubMed ID:
12075080
Type:
Article
Language:
en
ISSN:
0022-1317
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorJenson, Hal B-
dc.contributor.authorEnch, Yasmin-
dc.contributor.authorZhang, Yanjin-
dc.contributor.authorGao, Shou-Jiang-
dc.contributor.authorArrand, John R-
dc.contributor.authorMackett, Mike-
dc.date.accessioned2009-09-24T10:10:35Z-
dc.date.available2009-09-24T10:10:35Z-
dc.date.issued2002-07-
dc.identifier.citationCharacterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus). 2002, 83 (Pt 7):1621-33 J. Gen. Virol.en
dc.identifier.issn0022-1317-
dc.identifier.pmid12075080-
dc.identifier.urihttp://hdl.handle.net/10541/82462-
dc.description.abstractA gammaherpesvirus related to Epstein-Barr virus (EBV; Human herpesvirus 4) infects otherwise healthy common marmosets (Callithrix jacchus). Long-term culture of common marmoset peripheral blood lymphocytes resulted in outgrowth of spontaneously immortalized lymphoblastoid cell lines, primarily of B cell lineage. Electron microscopy of cells and supernatants showed herpesvirus particles. There were high rates of serological cross-reactivity to other herpesviruses (68-86%), but with very low geometric mean antibody titres [1:12 to human herpesvirus 6 and 1:14 to Herpesvirus papio (Cercopithecine herpesvirus 12)]. Sequence analysis of the conserved herpesvirus DNA polymerase gene showed that the virus is a member of the lymphocryptovirus subgroup and is most closely related to a lymphocryptovirus from rhesus macaques and is closely related to EBV and Herpesvirus papio. High seroprevalence (79%, with geometric mean antibody titre of 1:110) among 28 common marmosets from two geographically distinct colonies indicated that the virus is likely present in many common marmosets in captivity. A New World primate harbouring a lymphocryptovirus suggests that this subgroup arose much earlier than previously thought.en
dc.language.isoenen
dc.subject.meshAmino Acid Sequence-
dc.subject.meshAnimals-
dc.subject.meshAntibodies, Viral-
dc.subject.meshCallithrix-
dc.subject.meshCell Line-
dc.subject.meshCross Reactions-
dc.subject.meshDNA-Directed DNA Polymerase-
dc.subject.meshGammaherpesvirinae-
dc.subject.meshLeukocytes, Mononuclear-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshPhylogeny-
dc.subject.meshSequence Alignment-
dc.subject.meshSeroepidemiologic Studies-
dc.titleCharacterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus).en
dc.typeArticleen
dc.contributor.departmentDepartment of Pediatrics, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. jenson@uthscsa.eduen
dc.identifier.journalThe Journal of General Virologyen

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