Intranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/82452
Title:
Intranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation.
Authors:
Eyden, Brian P; Chorneyko, K A
Abstract:
A case of intranodal myofibroblastoma with amianthoid fibres was studied by histology, immunohistochemistry and electron microscopy, in a Canadian Caucasian male presenting with an inguinal mass which appeared following a sports injury. Tumour cells were spindled and formed haphazard interlacing fascicles with intervening areas of haemorrhage. They were positive for vimentin, alpha-smooth-muscle actin and HHF35. By electron microscopy, they displayed moderate numbers of rough endoplasmic reticulum cisternae, fine actin-sized filaments in cell processes, and discrete stretches of unambiguous lamina ('external' lamina), sometimes in association with short attachment plaques. The fibronectin fibrils and fibronexus junctions characteristic of myofibroblasts were not seen. The absence of fibronexus junctions and the presence of surface features typical of smooth-muscle cells (attachment plaques with overlying lamina) suggest that this tumour is not myofibroblastic but is exhibiting a degree of smooth-muscle differentiation. The findings confirm earlier observations suggesting that some intranodal myofibroblastomas are not myofibroblastic, but show a form of smooth-muscle differentiation.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom. Brian.Eyden@christie-tr.nwest.nhs.uk
Citation:
Intranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation., 33 (1-2):157-63 J. Submicrosc. Cytol. Pathol.
Journal:
Journal of Submicroscopic Cytology and Pathology
Issue Date:
2001
URI:
http://hdl.handle.net/10541/82452
PubMed ID:
11686397
Type:
Article
Language:
en
ISSN:
1122-9497
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian P-
dc.contributor.authorChorneyko, K A-
dc.date.accessioned2009-09-24T11:16:34Z-
dc.date.available2009-09-24T11:16:34Z-
dc.date.issued2001-
dc.identifier.citationIntranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation., 33 (1-2):157-63 J. Submicrosc. Cytol. Pathol.en
dc.identifier.issn1122-9497-
dc.identifier.pmid11686397-
dc.identifier.urihttp://hdl.handle.net/10541/82452-
dc.description.abstractA case of intranodal myofibroblastoma with amianthoid fibres was studied by histology, immunohistochemistry and electron microscopy, in a Canadian Caucasian male presenting with an inguinal mass which appeared following a sports injury. Tumour cells were spindled and formed haphazard interlacing fascicles with intervening areas of haemorrhage. They were positive for vimentin, alpha-smooth-muscle actin and HHF35. By electron microscopy, they displayed moderate numbers of rough endoplasmic reticulum cisternae, fine actin-sized filaments in cell processes, and discrete stretches of unambiguous lamina ('external' lamina), sometimes in association with short attachment plaques. The fibronectin fibrils and fibronexus junctions characteristic of myofibroblasts were not seen. The absence of fibronexus junctions and the presence of surface features typical of smooth-muscle cells (attachment plaques with overlying lamina) suggest that this tumour is not myofibroblastic but is exhibiting a degree of smooth-muscle differentiation. The findings confirm earlier observations suggesting that some intranodal myofibroblastomas are not myofibroblastic, but show a form of smooth-muscle differentiation.en
dc.language.isoenen
dc.subjectMuscle Tissue Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshActins-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymph Nodes-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscle, Smooth-
dc.subject.meshNeoplasms, Muscle Tissue-
dc.subject.meshOrganelles-
dc.subject.meshTumor Markers, Biological-
dc.subject.meshVimentin-
dc.titleIntranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom. Brian.Eyden@christie-tr.nwest.nhs.uken
dc.identifier.journalJournal of Submicroscopic Cytology and Pathologyen

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