Rapid screening of 2-[18F]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography-selective ion monitoring mass spectrometry (SPME-GC-SIMMS).

2.50
Hdl Handle:
http://hdl.handle.net/10541/82298
Title:
Rapid screening of 2-[18F]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography-selective ion monitoring mass spectrometry (SPME-GC-SIMMS).
Authors:
Kanu, A B; Dixon, M; Zu, Y Yin; Bailey, J; Gillies, James M; Zweit, Jamal; Thomas, C L P
Abstract:
A method compatible with radioactive samples, capable of detecting trace volatile components in a sample volume of ca. 1cm(3) of 2-[18F]-fluoro-2-deoxy-D-glucose solution is described. The approach, based on solid phase micro-extraction gas chromatography-mass spectrometry with a carboxen/polydimethylsiloxane based fibre, was optimised with respect to extraction time (10 min), extraction temperature (60 degrees C) and phase volume ratio (1). The analysis time, including extraction, was less than 20 min with linear responses for acetonitrile and ethanol over the ranges: 0.09-80 microg cm(-3) (22 degrees C, acetonitrile) and 0.78-79 microg cm(-3) (22 degrees C, ethanol). The detection limits were estimated to be ca. 0.78 microg cm(-3) for ethanol and 0.09 microg cm(-3) for acetonitrile. Stability studies indicated analyte losses of up to 75% over 24h and analysis of aged 2-[18F]FDG samples showed that levels of ethanol and acetonitrile were not less than 100 microg cm(-3), indicative of levels substantially greater than this in the original infusions given to human subjects.
Affiliation:
Department of Instrumentation and Analytical Science, UMIST, Manchester, UK.
Citation:
Rapid screening of 2-[18F]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography-selective ion monitoring mass spectrometry (SPME-GC-SIMMS). 2003, 58 (2):193-200 Appl Radiat Isot
Journal:
Applied Radiation and Isotopes
Issue Date:
Feb-2003
URI:
http://hdl.handle.net/10541/82298
DOI:
10.1016/S0969-8043(02)00293-2
PubMed ID:
12573318
Type:
Article
Language:
en
ISSN:
0969-8043
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorKanu, A B-
dc.contributor.authorDixon, M-
dc.contributor.authorZu, Y Yin-
dc.contributor.authorBailey, J-
dc.contributor.authorGillies, James M-
dc.contributor.authorZweit, Jamal-
dc.contributor.authorThomas, C L P-
dc.date.accessioned2009-09-23T11:42:22Z-
dc.date.available2009-09-23T11:42:22Z-
dc.date.issued2003-02-
dc.identifier.citationRapid screening of 2-[18F]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography-selective ion monitoring mass spectrometry (SPME-GC-SIMMS). 2003, 58 (2):193-200 Appl Radiat Isoten
dc.identifier.issn0969-8043-
dc.identifier.pmid12573318-
dc.identifier.doi10.1016/S0969-8043(02)00293-2-
dc.identifier.urihttp://hdl.handle.net/10541/82298-
dc.description.abstractA method compatible with radioactive samples, capable of detecting trace volatile components in a sample volume of ca. 1cm(3) of 2-[18F]-fluoro-2-deoxy-D-glucose solution is described. The approach, based on solid phase micro-extraction gas chromatography-mass spectrometry with a carboxen/polydimethylsiloxane based fibre, was optimised with respect to extraction time (10 min), extraction temperature (60 degrees C) and phase volume ratio (1). The analysis time, including extraction, was less than 20 min with linear responses for acetonitrile and ethanol over the ranges: 0.09-80 microg cm(-3) (22 degrees C, acetonitrile) and 0.78-79 microg cm(-3) (22 degrees C, ethanol). The detection limits were estimated to be ca. 0.78 microg cm(-3) for ethanol and 0.09 microg cm(-3) for acetonitrile. Stability studies indicated analyte losses of up to 75% over 24h and analysis of aged 2-[18F]FDG samples showed that levels of ethanol and acetonitrile were not less than 100 microg cm(-3), indicative of levels substantially greater than this in the original infusions given to human subjects.en
dc.language.isoenen
dc.subject.meshCalibration-
dc.subject.meshDrug Contamination-
dc.subject.meshFluorodeoxyglucose F18-
dc.subject.meshGas Chromatography-Mass Spectrometry-
dc.subject.meshOrganic Chemicals-
dc.titleRapid screening of 2-[18F]-fluoro-2-deoxy-D-glucose infusions for volatile organic compound contaminants by solid phase microextraction with gas chromatography-selective ion monitoring mass spectrometry (SPME-GC-SIMMS).en
dc.typeArticleen
dc.contributor.departmentDepartment of Instrumentation and Analytical Science, UMIST, Manchester, UK.en
dc.identifier.journalApplied Radiation and Isotopesen
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