The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.

2.50
Hdl Handle:
http://hdl.handle.net/10541/82296
Title:
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Authors:
Lawrence, Nicholas J; Rennison, David; McGown, Alan T; Hadfield, John A
Abstract:
The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.
Affiliation:
Department of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, UK. lawrencenj1@cardiff.ac.uk
Citation:
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. 2003, 13 (21):3759-63 Bioorg. Med. Chem. Lett.
Journal:
Bioorganic & Medicinal Chemistry Letters
Issue Date:
3-Nov-2003
URI:
http://hdl.handle.net/10541/82296
DOI:
10.1016/j.bmcl.2003.07.003
PubMed ID:
14552774
Type:
Article
Language:
en
ISSN:
0960-894X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLawrence, Nicholas J-
dc.contributor.authorRennison, David-
dc.contributor.authorMcGown, Alan T-
dc.contributor.authorHadfield, John A-
dc.date.accessioned2009-09-23T11:33:46Z-
dc.date.available2009-09-23T11:33:46Z-
dc.date.issued2003-11-03-
dc.identifier.citationThe total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. 2003, 13 (21):3759-63 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X-
dc.identifier.pmid14552774-
dc.identifier.doi10.1016/j.bmcl.2003.07.003-
dc.identifier.urihttp://hdl.handle.net/10541/82296-
dc.description.abstractThe naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshBenzofurans-
dc.subject.meshCell Cycle-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshFlavonoids-
dc.subject.meshG2 Phase-
dc.subject.meshHumans-
dc.subject.meshIndicators and Reagents-
dc.subject.meshK562 Cells-
dc.subject.meshMitosis-
dc.subject.meshModels, Molecular-
dc.subject.meshMolecular Conformation-
dc.subject.meshProtein Binding-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshTetrazolium Salts-
dc.subject.meshThiazoles-
dc.subject.meshTubulin-
dc.subject.meshUvaria-
dc.titleThe total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, UK. lawrencenj1@cardiff.ac.uken
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen

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