The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue.

2.50
Hdl Handle:
http://hdl.handle.net/10541/82275
Title:
The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue.
Authors:
Heighway, Jim; Margison, Geoffrey P; Santibanez-Koref, Mauro F
Abstract:
O6-Alkylguanine-DNA alkyltransferase (MGMT) confers resistance to many of the mutagenic and toxic effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The levels of expression of this protein are of interest in relation to the prevention and treatment of cancer in man. They vary widely between individuals, and the basis of this variation is not understood. RT-PCR-RFLP analysis of mRNA from normal human lung tissue reveals that the two MGMT alleles are frequently expressed at different levels, indicating that there is a genetic component to inter-individual variation of MGMT levels and that at least some of this variation maps close to or within the MGMT locus.
Affiliation:
Roy Castle International Centre for Lung Cancer Research, 200 London Road, Liverpool L3 9TA, UK.
Citation:
The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue. 2003, 24 (10):1691-4 Carcinogenesis
Journal:
Carcinogenesis
Issue Date:
Oct-2003
URI:
http://hdl.handle.net/10541/82275
DOI:
10.1093/carcin/bgg124
PubMed ID:
12896905
Type:
Article
Language:
en
ISSN:
0143-3334
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHeighway, Jim-
dc.contributor.authorMargison, Geoffrey P-
dc.contributor.authorSantibanez-Koref, Mauro F-
dc.date.accessioned2009-09-23T10:25:41Z-
dc.date.available2009-09-23T10:25:41Z-
dc.date.issued2003-10-
dc.identifier.citationThe alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue. 2003, 24 (10):1691-4 Carcinogenesisen
dc.identifier.issn0143-3334-
dc.identifier.pmid12896905-
dc.identifier.doi10.1093/carcin/bgg124-
dc.identifier.urihttp://hdl.handle.net/10541/82275-
dc.description.abstractO6-Alkylguanine-DNA alkyltransferase (MGMT) confers resistance to many of the mutagenic and toxic effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The levels of expression of this protein are of interest in relation to the prevention and treatment of cancer in man. They vary widely between individuals, and the basis of this variation is not understood. RT-PCR-RFLP analysis of mRNA from normal human lung tissue reveals that the two MGMT alleles are frequently expressed at different levels, indicating that there is a genetic component to inter-individual variation of MGMT levels and that at least some of this variation maps close to or within the MGMT locus.en
dc.language.isoenen
dc.subject.meshAlleles-
dc.subject.meshDNA Repair-
dc.subject.meshHumans-
dc.subject.meshLung-
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase-
dc.subject.meshRNA, Messenger-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshTranscription, Genetic-
dc.titleThe alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue.en
dc.typeArticleen
dc.contributor.departmentRoy Castle International Centre for Lung Cancer Research, 200 London Road, Liverpool L3 9TA, UK.en
dc.identifier.journalCarcinogenesisen

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