Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women.

2.50
Hdl Handle:
http://hdl.handle.net/10541/82233
Title:
Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women.
Authors:
Davidson, Emma J; Davidson, Judith A; Sterling, Jane C; Baldwin, Peter J W; Kitchener, Henry C; Stern, Peter L
Abstract:
Polymorphisms in human leukocyte antigen (HLA) genes have been implicated in the risk for developing human papillomavirus (HPV)-associated cervical neoplasia. By comparison with local cadaver controls typed for HLA class I (n = 946) and II (n = 144) antigens, HPV-16-positive high grade vulval intraepithelial neoplasia patients (n = 42) showed significantly different frequencies of HLA-A2 [odds ratio (OR), 2.1; confidence interval (CI), 1.4-3.9], HLA-B7 (OR, 2.6; CI, 1.4-4.7), HLA-DRB1*01(01/02/04) (OR, 0.1; CI, 0.03-0.5), HLA-DRB1*11 (OR, 3.3; CI, 1.4-7.1), HLA-DRB1*13 (OR, 0), HLA-DQB1*05 (OR, 0.2; CI, 0.05-0.6), and HLA-DQB1*03032 (OR, 4.6; CI, 1.5-14.0). With the exception of HLA-B7 and HLA-DRB1*11, these significant differences were also seen comparative to local HPV-16-positive cervical carcinoma patients (n = 114), suggesting a specific immunogenetic contribution that is independent of HPV-16 infection in high-grade vulval intraepithelial neoplasia. Such factors are important to the development of HPV vaccines for treatment of cervical and vulval neoplasia.
Affiliation:
Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom.
Citation:
Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. 2003, 63 (2):400-3 Cancer Res.
Journal:
Cancer Research
Issue Date:
15-Jan-2003
URI:
http://hdl.handle.net/10541/82233
PubMed ID:
12543794
Type:
Article
Language:
en
ISSN:
0008-5472
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDavidson, Emma J-
dc.contributor.authorDavidson, Judith A-
dc.contributor.authorSterling, Jane C-
dc.contributor.authorBaldwin, Peter J W-
dc.contributor.authorKitchener, Henry C-
dc.contributor.authorStern, Peter L-
dc.date.accessioned2009-09-23T09:20:20Z-
dc.date.available2009-09-23T09:20:20Z-
dc.date.issued2003-01-15-
dc.identifier.citationAssociation between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. 2003, 63 (2):400-3 Cancer Res.en
dc.identifier.issn0008-5472-
dc.identifier.pmid12543794-
dc.identifier.urihttp://hdl.handle.net/10541/82233-
dc.description.abstractPolymorphisms in human leukocyte antigen (HLA) genes have been implicated in the risk for developing human papillomavirus (HPV)-associated cervical neoplasia. By comparison with local cadaver controls typed for HLA class I (n = 946) and II (n = 144) antigens, HPV-16-positive high grade vulval intraepithelial neoplasia patients (n = 42) showed significantly different frequencies of HLA-A2 [odds ratio (OR), 2.1; confidence interval (CI), 1.4-3.9], HLA-B7 (OR, 2.6; CI, 1.4-4.7), HLA-DRB1*01(01/02/04) (OR, 0.1; CI, 0.03-0.5), HLA-DRB1*11 (OR, 3.3; CI, 1.4-7.1), HLA-DRB1*13 (OR, 0), HLA-DQB1*05 (OR, 0.2; CI, 0.05-0.6), and HLA-DQB1*03032 (OR, 4.6; CI, 1.5-14.0). With the exception of HLA-B7 and HLA-DRB1*11, these significant differences were also seen comparative to local HPV-16-positive cervical carcinoma patients (n = 114), suggesting a specific immunogenetic contribution that is independent of HPV-16 infection in high-grade vulval intraepithelial neoplasia. Such factors are important to the development of HPV vaccines for treatment of cervical and vulval neoplasia.en
dc.language.isoenen
dc.subjectVulvar Canceren
dc.subjectTumour Virus Infectionsen
dc.subject.meshBiopsy-
dc.subject.meshFemale-
dc.subject.meshHLA-A Antigens-
dc.subject.meshHLA-DR Antigens-
dc.subject.meshHumans-
dc.subject.meshPapillomaviridae-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshTumor Virus Infections-
dc.subject.meshVulvar Neoplasms-
dc.titleAssociation between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women.en
dc.typeArticleen
dc.contributor.departmentImmunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom.en
dc.identifier.journalCancer Researchen

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