2.50
Hdl Handle:
http://hdl.handle.net/10541/82216
Title:
Variability and regulation of O6-alkylguanine-DNA alkyltransferase.
Authors:
Margison, Geoffrey P; Povey, Andrew C; Kaina, Bernd; Santibanez-Koref, Mauro F
Abstract:
O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.
Affiliation:
Cancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. gmargison@picr.man.ac.uk
Citation:
Variability and regulation of O6-alkylguanine-DNA alkyltransferase. 2003, 24 (4):625-35 Carcinogenesis
Journal:
Carcinogenesis
Issue Date:
Apr-2003
URI:
http://hdl.handle.net/10541/82216
DOI:
10.1093/carcin/bgg005
PubMed ID:
12727789
Type:
Article
Language:
en
ISSN:
0143-3334
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMargison, Geoffrey P-
dc.contributor.authorPovey, Andrew C-
dc.contributor.authorKaina, Bernd-
dc.contributor.authorSantibanez-Koref, Mauro F-
dc.date.accessioned2009-09-23T09:00:10Z-
dc.date.available2009-09-23T09:00:10Z-
dc.date.issued2003-04-
dc.identifier.citationVariability and regulation of O6-alkylguanine-DNA alkyltransferase. 2003, 24 (4):625-35 Carcinogenesisen
dc.identifier.issn0143-3334-
dc.identifier.pmid12727789-
dc.identifier.doi10.1093/carcin/bgg005-
dc.identifier.urihttp://hdl.handle.net/10541/82216-
dc.description.abstractO(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.en
dc.language.isoenen
dc.subject.meshAlkylation-
dc.subject.meshAmino Acid Sequence-
dc.subject.meshChromatin-
dc.subject.meshDNA-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase-
dc.subject.meshPhosphorylation-
dc.subject.meshPromoter Regions, Genetic-
dc.subject.meshSequence Homology, Amino Acid-
dc.subject.meshTranscription Factors-
dc.titleVariability and regulation of O6-alkylguanine-DNA alkyltransferase.en
dc.typeArticleen
dc.contributor.departmentCancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. gmargison@picr.man.ac.uken
dc.identifier.journalCarcinogenesisen
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