2.50
Hdl Handle:
http://hdl.handle.net/10541/82003
Title:
Growth hormone receptor antagonists therapy for acromegaly.
Authors:
Parkinson, Craig; Trainer, Peter J
Abstract:
Knowledge of the interaction between growth hormone (GH) and the growth hormone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able to block the action of GH at the cellular level offers greater specificity of effect compared with current medical therapies and is not dependent on tumour characteristics. This chapter reviews the interaction between GH and the GHR, and discusses the outstanding issues regarding GHR antagonist therapy in acromegaly.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
Growth hormone receptor antagonists therapy for acromegaly. 1999, 13 (3):419-30 Baillieres Best Pract Res Clin Endocrinol Metab
Journal:
Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism
Issue Date:
Oct-1999
URI:
http://hdl.handle.net/10541/82003
PubMed ID:
10909433
Type:
Article
Language:
en
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorParkinson, Craig-
dc.contributor.authorTrainer, Peter J-
dc.date.accessioned2009-09-22T11:56:44Z-
dc.date.available2009-09-22T11:56:44Z-
dc.date.issued1999-10-
dc.identifier.citationGrowth hormone receptor antagonists therapy for acromegaly. 1999, 13 (3):419-30 Baillieres Best Pract Res Clin Endocrinol Metaben
dc.identifier.pmid10909433-
dc.identifier.urihttp://hdl.handle.net/10541/82003-
dc.description.abstractKnowledge of the interaction between growth hormone (GH) and the growth hormone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able to block the action of GH at the cellular level offers greater specificity of effect compared with current medical therapies and is not dependent on tumour characteristics. This chapter reviews the interaction between GH and the GHR, and discusses the outstanding issues regarding GHR antagonist therapy in acromegaly.en
dc.language.isoenen
dc.subject.meshAcromegaly-
dc.subject.meshAnimals-
dc.subject.meshDimerization-
dc.subject.meshDrug Design-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshReceptors, Somatotropin-
dc.subject.meshSignal Transduction-
dc.titleGrowth hormone receptor antagonists therapy for acromegaly.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalBaillière's Best Practice & Research. Clinical Endocrinology & Metabolismen

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