2.50
Hdl Handle:
http://hdl.handle.net/10541/81233
Title:
Leiomyosarcoma showing partial synthetic-phase differentiation.
Authors:
Eyden, Brian P; Banerjee, Saumitra S
Abstract:
An unusual leiomyosarcoma in the thigh of a 53-year-old woman is described. Tumor cells were spindled and positive for muscle immuno-markers. Some cells exhibited typical smooth-muscle ultrastructure--abundant myofilaments, focal densities, attachment plaques, plasmalemmal caveolae, and lamina. Others had fewer myofilaments and prominent rough endoplasmic reticulum. These features indicated a variable phenotype that included synthetic-phase (matrigenic) differentiation. Synthetic-phase cells were distinguished from myofibroblasts by typical smooth-muscle surface features in the absence of fibronexus junctions. In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation.
Affiliation:
Christie Hospital NHS Trust, Manchester, United Kingdom. Bryan.Eyden@christie-tr.nwest.nhs.uk
Citation:
Leiomyosarcoma showing partial synthetic-phase differentiation., 26 (5):335-40 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
2002
URI:
http://hdl.handle.net/10541/81233
DOI:
10.1080/01913120290104629
PubMed ID:
12396245
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian P-
dc.contributor.authorBanerjee, Saumitra S-
dc.date.accessioned2009-09-16T10:02:18Z-
dc.date.available2009-09-16T10:02:18Z-
dc.date.issued2002-
dc.identifier.citationLeiomyosarcoma showing partial synthetic-phase differentiation., 26 (5):335-40 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid12396245-
dc.identifier.doi10.1080/01913120290104629-
dc.identifier.urihttp://hdl.handle.net/10541/81233-
dc.description.abstractAn unusual leiomyosarcoma in the thigh of a 53-year-old woman is described. Tumor cells were spindled and positive for muscle immuno-markers. Some cells exhibited typical smooth-muscle ultrastructure--abundant myofilaments, focal densities, attachment plaques, plasmalemmal caveolae, and lamina. Others had fewer myofilaments and prominent rough endoplasmic reticulum. These features indicated a variable phenotype that included synthetic-phase (matrigenic) differentiation. Synthetic-phase cells were distinguished from myofibroblasts by typical smooth-muscle surface features in the absence of fibronexus junctions. In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation.en
dc.language.isoenen
dc.subjectSecond Primary Canceren
dc.subjectSoft Tissue Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLeiomyosarcoma-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshS Phase-
dc.subject.meshSoft Tissue Neoplasms-
dc.subject.meshThigh-
dc.subject.meshTumor Markers, Biological-
dc.titleLeiomyosarcoma showing partial synthetic-phase differentiation.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, Manchester, United Kingdom. Bryan.Eyden@christie-tr.nwest.nhs.uken
dc.identifier.journalUltrastructural Pathologyen
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