Contribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors.

2.50
Hdl Handle:
http://hdl.handle.net/10541/81151
Title:
Contribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors.
Authors:
Eyden, Brian P; Chorneyko, Katherine A; Shanks, Jonathan H; Menasce, Lia P; Banerjee, Saumitra S
Abstract:
Eighty-two mesenchymal tumors of the gastrointestinal tract were examined by electron microscopy for the purposes of subtyping for diagnostic precision and of understanding cellular differentiation. Tumors were subclassified into leiomyoma/leiomyosarcoma, tumors of the interstitial cell of Cajal (equivalent to traditionally defined GISTs [Miettinen et al. Hum Pathol. 1999; 30:1213-1220; Mod Pathol. 2000; 13:1134-1142]), gastrointestinal autonomic nerve tumors (GANTs), and fibroblastic and myofibroblastic tumors, using criteria from the literature. Leiomyoma/leiomyosarcoma were diagnosed by myofilaments, attachment plaques, plasmalemmal caveolae, and lamina; GIST by processes or cell bodies full of intermediate filaments, solitary focal densities amid intermediate filaments, attachment plaques with incomplete lamina, scarce myofilaments, and smooth endoplasmic reticulum; GANTs by neuroendocrine granules, cell bodies/processes full of intermediate filaments (more rarely microtubules), and smooth endoplasmic reticulum; fibroblastic/myofibroblastic tumors by abundant rough endoplasmic reticulum, myofilaments, and fibronexuses. Seventy-three tumors (89%) were successfully subclassified, as 5 leiomyoma/leiomyosarcoma (6%), 36 GISTs (44%), 22 GANTs (27%), 10 fibroblastic and myofibroblastic tumors (12%). Results indicated overlap between poorly differentiated leiomyosarcoma and GIST, and between GIST and GANT. GANT is emphasized as a neuronal tumor identifiable by electron microscopy, and thereby distinguishable from GIST.
Affiliation:
Department of Histopathology, Christie Hospital, Manchester, United Kingdom. brian.eyden@christie-tr.nwest.nhs.uk
Citation:
Contribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors., 26 (5):269-85 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
2002
URI:
http://hdl.handle.net/10541/81151
DOI:
10.1080/01913120290104548
PubMed ID:
12396237
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian P-
dc.contributor.authorChorneyko, Katherine A-
dc.contributor.authorShanks, Jonathan H-
dc.contributor.authorMenasce, Lia P-
dc.contributor.authorBanerjee, Saumitra S-
dc.date.accessioned2009-09-15T16:36:54Z-
dc.date.available2009-09-15T16:36:54Z-
dc.date.issued2002-
dc.identifier.citationContribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors., 26 (5):269-85 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid12396237-
dc.identifier.doi10.1080/01913120290104548-
dc.identifier.urihttp://hdl.handle.net/10541/81151-
dc.description.abstractEighty-two mesenchymal tumors of the gastrointestinal tract were examined by electron microscopy for the purposes of subtyping for diagnostic precision and of understanding cellular differentiation. Tumors were subclassified into leiomyoma/leiomyosarcoma, tumors of the interstitial cell of Cajal (equivalent to traditionally defined GISTs [Miettinen et al. Hum Pathol. 1999; 30:1213-1220; Mod Pathol. 2000; 13:1134-1142]), gastrointestinal autonomic nerve tumors (GANTs), and fibroblastic and myofibroblastic tumors, using criteria from the literature. Leiomyoma/leiomyosarcoma were diagnosed by myofilaments, attachment plaques, plasmalemmal caveolae, and lamina; GIST by processes or cell bodies full of intermediate filaments, solitary focal densities amid intermediate filaments, attachment plaques with incomplete lamina, scarce myofilaments, and smooth endoplasmic reticulum; GANTs by neuroendocrine granules, cell bodies/processes full of intermediate filaments (more rarely microtubules), and smooth endoplasmic reticulum; fibroblastic/myofibroblastic tumors by abundant rough endoplasmic reticulum, myofilaments, and fibronexuses. Seventy-three tumors (89%) were successfully subclassified, as 5 leiomyoma/leiomyosarcoma (6%), 36 GISTs (44%), 22 GANTs (27%), 10 fibroblastic and myofibroblastic tumors (12%). Results indicated overlap between poorly differentiated leiomyosarcoma and GIST, and between GIST and GANT. GANT is emphasized as a neuronal tumor identifiable by electron microscopy, and thereby distinguishable from GIST.en
dc.language.isoenen
dc.subjectGastrointestinal Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAutonomic Pathways-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshFemale-
dc.subject.meshFibroblasts-
dc.subject.meshGastrointestinal Neoplasms-
dc.subject.meshHumans-
dc.subject.meshLeiomyoma-
dc.subject.meshLeiomyosarcoma-
dc.subject.meshMale-
dc.subject.meshMesoderm-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshMyenteric Plexus-
dc.subject.meshNeurosecretory Systems-
dc.titleContribution of electron microscopy to understanding cellular differentiation in mesenchymal tumors of the gastrointestinal tract: a study of 82 tumors.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, United Kingdom. brian.eyden@christie-tr.nwest.nhs.uken
dc.identifier.journalUltrastructural Pathologyen

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