2.50
Hdl Handle:
http://hdl.handle.net/10541/81136
Title:
Intra-tumoural microvessel density in human solid tumours.
Authors:
Hasan, Jurjees; Byers, Richard J; Jayson, Gordon C ( 0000-0002-8515-8944 )
Abstract:
Over the last decade assessment of angiogenesis has emerged as a potentially useful biological prognostic and predictive factor in human solid tumours. With the development of highly specific endothelial markers that can be assessed in histological archival specimens, several quantitative studies have been performed in various solid tumours. The majority of published studies have shown a positive correlation between intra-tumoural microvessel density, a measure of tumour angiogenesis, and prognosis in solid tumours. A minority of studies have not demonstrated an association and this may be attributed to significant differences in the methodologies employed for sample selection, immunostaining techniques, vessel counting and statistical analysis, although a number of biological differences may account for the discrepancy. In this review we evaluate the quantification of angiogenesis by immunohistochemistry, the relationship between tumour vascularity and metastasis, and the clinicopathological studies correlating intra-tumoral microvessel density with prognosis and response to anti-cancer therapy. In view of the extensive nature of this retrospective body of data, comparative studies are needed to identify the optimum technique and endothelial antigens (activated or pan-endothelial antigens) but subsequently prospective studies that allocate treatment on the basis of microvessel density are required.
Affiliation:
Cancer Research UK Department of Medical Oncology, Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX, UK.
Citation:
Intra-tumoural microvessel density in human solid tumours. 2002, 86 (10):1566-77 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
20-May-2002
URI:
http://hdl.handle.net/10541/81136
DOI:
10.1038/sj.bjc.6600315
PubMed ID:
12085206
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHasan, Jurjees-
dc.contributor.authorByers, Richard J-
dc.contributor.authorJayson, Gordon C-
dc.date.accessioned2009-09-15T14:49:44Z-
dc.date.available2009-09-15T14:49:44Z-
dc.date.issued2002-05-20-
dc.identifier.citationIntra-tumoural microvessel density in human solid tumours. 2002, 86 (10):1566-77 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid12085206-
dc.identifier.doi10.1038/sj.bjc.6600315-
dc.identifier.urihttp://hdl.handle.net/10541/81136-
dc.description.abstractOver the last decade assessment of angiogenesis has emerged as a potentially useful biological prognostic and predictive factor in human solid tumours. With the development of highly specific endothelial markers that can be assessed in histological archival specimens, several quantitative studies have been performed in various solid tumours. The majority of published studies have shown a positive correlation between intra-tumoural microvessel density, a measure of tumour angiogenesis, and prognosis in solid tumours. A minority of studies have not demonstrated an association and this may be attributed to significant differences in the methodologies employed for sample selection, immunostaining techniques, vessel counting and statistical analysis, although a number of biological differences may account for the discrepancy. In this review we evaluate the quantification of angiogenesis by immunohistochemistry, the relationship between tumour vascularity and metastasis, and the clinicopathological studies correlating intra-tumoral microvessel density with prognosis and response to anti-cancer therapy. In view of the extensive nature of this retrospective body of data, comparative studies are needed to identify the optimum technique and endothelial antigens (activated or pan-endothelial antigens) but subsequently prospective studies that allocate treatment on the basis of microvessel density are required.en
dc.language.isoenen
dc.subjectCancer Metastasisen
dc.subjectCancer Proteinsen
dc.subjectCanceren
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshDrug Resistance, Neoplasm-
dc.subject.meshEndothelial Growth Factors-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymphokines-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshNeoplasms-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshPlasminogen Activator Inhibitor 1-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPrognosis-
dc.subject.meshReceptor Protein-Tyrosine Kinases-
dc.subject.meshReceptors, Growth Factor-
dc.subject.meshReceptors, Vascular Endothelial Growth Factor-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshSurvival Analysis-
dc.subject.meshThymidine Phosphorylase-
dc.subject.meshUrokinase-Type Plasminogen Activator-
dc.subject.meshVascular Endothelial Growth Factor A-
dc.subject.meshVascular Endothelial Growth Factors-
dc.titleIntra-tumoural microvessel density in human solid tumours.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX, UK.en
dc.identifier.journalBritish Journal of Canceren

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