Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model.

2.50
Hdl Handle:
http://hdl.handle.net/10541/81113
Title:
Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model.
Authors:
Jackson, A; Haroon, H A; Zhu, X P; Li, K L; Thacker, N A; Jayson, Gordon C ( 0000-0002-8515-8944 )
Abstract:
We have applied a novel pharmacokinetic model of the distribution of contrast media to dynamic contrast-enhanced MRI data from patients with hepatic neoplasms. The model uses data collected during the passage of a bolus of contrast medium and allows breath-hold image acquisition. The aims of the study were to investigate the feasibility of permeability mapping using the first pass technique and breath-hold acquisitions, and to examine the reproducibility of the technique and the effect of the liver's dual vascular supply on the assumptions of the model. Imaging was performed in 14 patients with hepatic neoplasms. Dynamic data clearly demonstrated differences in the timing and shape of the contrast medium concentration-time course curve in the systemic arterial and portal venous systems. Mapping of the arrival time (T(0)) of contrast medium allowed identification of tissue supplied by the hepatic arteries and portal vein. Hepatic tumours all showed typical hepatic arterial enhancement. Repeated measurements of endothelial permeability surface area product (k(fp)) and relative blood volume (rBV), performed in five patients, showed excellent reproducibility with variance ratios (V(r)) of 0.134 and 0.113, respectively. Measurement of enhancing tumour volume was also highly reproducible (V(r) = 0.096) and this was further improved by the use of T(0) maps to identify pixels supplied by the hepatic artery (V(r) = 0.026). Estimates of k(fp) and rBV in normal hepatic tissue supplied by the portal vein were highly inaccurate and these pixels were identified by use of the T(0) parameter and excluded from the analysis. In conclusion, dynamic MRI contrast enhancement combined with a pharmacokinetic model of the distribution of contrast media in the first pass allows us to produce highly reproducible parametric maps of k(fp) and rBV from hepatic tumours that are supplied by the hepatic arterial system using breath-hold acquisitions.
Affiliation:
Division of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, Manchester M13 9PT, UK. alan.jackson@man.ac.uk
Citation:
Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model. 2002, 15 (2):164-73 NMR Biomed
Journal:
NMR in Biomedicine
Issue Date:
Apr-2002
URI:
http://hdl.handle.net/10541/81113
PubMed ID:
11870912
Type:
Article
Language:
en
ISSN:
0952-3480
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJackson, A-
dc.contributor.authorHaroon, H A-
dc.contributor.authorZhu, X P-
dc.contributor.authorLi, K L-
dc.contributor.authorThacker, N A-
dc.contributor.authorJayson, Gordon C-
dc.date.accessioned2009-09-15T13:40:36Z-
dc.date.available2009-09-15T13:40:36Z-
dc.date.issued2002-04-
dc.identifier.citationBreath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model. 2002, 15 (2):164-73 NMR Biomeden
dc.identifier.issn0952-3480-
dc.identifier.pmid11870912-
dc.identifier.urihttp://hdl.handle.net/10541/81113-
dc.description.abstractWe have applied a novel pharmacokinetic model of the distribution of contrast media to dynamic contrast-enhanced MRI data from patients with hepatic neoplasms. The model uses data collected during the passage of a bolus of contrast medium and allows breath-hold image acquisition. The aims of the study were to investigate the feasibility of permeability mapping using the first pass technique and breath-hold acquisitions, and to examine the reproducibility of the technique and the effect of the liver's dual vascular supply on the assumptions of the model. Imaging was performed in 14 patients with hepatic neoplasms. Dynamic data clearly demonstrated differences in the timing and shape of the contrast medium concentration-time course curve in the systemic arterial and portal venous systems. Mapping of the arrival time (T(0)) of contrast medium allowed identification of tissue supplied by the hepatic arteries and portal vein. Hepatic tumours all showed typical hepatic arterial enhancement. Repeated measurements of endothelial permeability surface area product (k(fp)) and relative blood volume (rBV), performed in five patients, showed excellent reproducibility with variance ratios (V(r)) of 0.134 and 0.113, respectively. Measurement of enhancing tumour volume was also highly reproducible (V(r) = 0.096) and this was further improved by the use of T(0) maps to identify pixels supplied by the hepatic artery (V(r) = 0.026). Estimates of k(fp) and rBV in normal hepatic tissue supplied by the portal vein were highly inaccurate and these pixels were identified by use of the T(0) parameter and excluded from the analysis. In conclusion, dynamic MRI contrast enhancement combined with a pharmacokinetic model of the distribution of contrast media in the first pass allows us to produce highly reproducible parametric maps of k(fp) and rBV from hepatic tumours that are supplied by the hepatic arterial system using breath-hold acquisitions.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectCavernous Haemangiomaen
dc.subjectLiver Canceren
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBlood Vessels-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshContrast Media-
dc.subject.meshFemale-
dc.subject.meshGadolinium DTPA-
dc.subject.meshHemangioma, Cavernous-
dc.subject.meshHumans-
dc.subject.meshInhalation-
dc.subject.meshLiver Neoplasms-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPermeability-
dc.subject.meshReproducibility of Results-
dc.titleBreath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model.en
dc.typeArticleen
dc.contributor.departmentDivision of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, Manchester M13 9PT, UK. alan.jackson@man.ac.uken
dc.identifier.journalNMR in Biomedicineen

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