Identical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80274
Title:
Identical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results.
Authors:
Burgers, J A; Arance, Ana; Ashcroft, Linda; Hodgetts, Jackie; Lomax, Lyn; Thatcher, Nick
Abstract:
Patients who are treated within clinical trials may have a survival benefit dependent on being a trial participant. A number of factors may produce such beneficial outcome including more rigorous adherence to a peer reviewed trial protocol, management by an experienced treatment team, being treated in a specialist centre etc. The current investigation compared patients treated on and off trial with the same standard arm treatment regimen. The results could then be interpreted without the confounding factors of differing treatment regimens, treatment teams or treatment hospitals. The results demonstrated given these circumstances that survival was no different for patients participating in a randomised trial compared with a group of patients similarly treated who were not eligible for trial entry or who declined randomisation. These results were obtained by the rigorous adherence to a defined protocol with the invaluable assistance of designated lung cancer staff.
Affiliation:
University Hospital Rotterdam, Department of Pulmonary Diseases. P.O. Box 5201, 3008 AE Rotterdam, The Netherlands.
Citation:
Identical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results. 2002, 87 (5):562-6 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
27-Aug-2002
URI:
http://hdl.handle.net/10541/80274
DOI:
10.1038/sj.bjc.6600433
PubMed ID:
12189557
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBurgers, J A-
dc.contributor.authorArance, Ana-
dc.contributor.authorAshcroft, Linda-
dc.contributor.authorHodgetts, Jackie-
dc.contributor.authorLomax, Lyn-
dc.contributor.authorThatcher, Nick-
dc.date.accessioned2009-09-08T11:09:49Z-
dc.date.available2009-09-08T11:09:49Z-
dc.date.issued2002-08-27-
dc.identifier.citationIdentical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results. 2002, 87 (5):562-6 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid12189557-
dc.identifier.doi10.1038/sj.bjc.6600433-
dc.identifier.urihttp://hdl.handle.net/10541/80274-
dc.description.abstractPatients who are treated within clinical trials may have a survival benefit dependent on being a trial participant. A number of factors may produce such beneficial outcome including more rigorous adherence to a peer reviewed trial protocol, management by an experienced treatment team, being treated in a specialist centre etc. The current investigation compared patients treated on and off trial with the same standard arm treatment regimen. The results could then be interpreted without the confounding factors of differing treatment regimens, treatment teams or treatment hospitals. The results demonstrated given these circumstances that survival was no different for patients participating in a randomised trial compared with a group of patients similarly treated who were not eligible for trial entry or who declined randomisation. These results were obtained by the rigorous adherence to a defined protocol with the invaluable assistance of designated lung cancer staff.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshClinical Trials, Phase III as Topic-
dc.subject.meshCyclophosphamide-
dc.subject.meshDoxorubicin-
dc.subject.meshEtoposide-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLife Tables-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPatient Acceptance of Health Care-
dc.subject.meshPatient Selection-
dc.subject.meshPrognosis-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshRemission Induction-
dc.subject.meshRetrospective Studies-
dc.subject.meshSurvival Analysis-
dc.subject.meshTreatment Refusal-
dc.titleIdentical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results.en
dc.typeArticleen
dc.contributor.departmentUniversity Hospital Rotterdam, Department of Pulmonary Diseases. P.O. Box 5201, 3008 AE Rotterdam, The Netherlands.en
dc.identifier.journalBritish Journal of Canceren

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.