Parathyroid hormone-related peptide: expression in prostate cancer bone metastases.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80251
Title:
Parathyroid hormone-related peptide: expression in prostate cancer bone metastases.
Authors:
Bryden, A A G; Islam, S; Freemont, Anthony J; Shanks, Jonathan H; George, Nicholas J; Clarke, Noel W ( 0000-0001-7776-8059 )
Abstract:
Parathyroid hormone-related peptide (PTHrP) is a regulatory protein associated with cell growth in non-osseous tissues and with osteoclast stimulation in bone. It has been implicated in the pathogenesis of bone metastases, particularly in breast carcinoma. PTHrP is widely expressed in primary prostate cancers, but there are few reports of its expression in prostatic metastases. The aim of this study was to examine the expression of PTHrP in bone metastases from patients with untreated adenocarcinoma of the prostate. Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were identified. These were immunohistochemically stained for PTHrP using a murine monoclonal antibody (PTHLP[Ab1]) and the streptavidin-biotin complex technique. Intensity of staining for PTHrP was graded by two observers. In total, PTHrP expression was positive in 5/10 specimens. This was graded as moderate in four and weak in one. In those specimens with positive staining, the expression varied between cells. There was no obvious association between expression of PTHrP and tumour differentiation. PTHrP is expressed in prostatic bone metastases and may have a role in their pathogenesis and pathophysiology. However, expression is not universal.
Affiliation:
Christie and Hope Hospitals, Manchester, UK. gbryden@hotmail.com
Citation:
Parathyroid hormone-related peptide: expression in prostate cancer bone metastases. 2002, 5 (1):59-62 Prostate Cancer Prostatic Dis.
Journal:
Prostate Cancer and Prostatic Diseases
Issue Date:
2002
URI:
http://hdl.handle.net/10541/80251
DOI:
10.1038/sj.pcan.4500553
PubMed ID:
15195132
Type:
Article
Language:
en
ISSN:
1365-7852
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBryden, A A G-
dc.contributor.authorIslam, S-
dc.contributor.authorFreemont, Anthony J-
dc.contributor.authorShanks, Jonathan H-
dc.contributor.authorGeorge, Nicholas J-
dc.contributor.authorClarke, Noel W-
dc.date.accessioned2009-09-08T10:59:15Z-
dc.date.available2009-09-08T10:59:15Z-
dc.date.issued2002-
dc.identifier.citationParathyroid hormone-related peptide: expression in prostate cancer bone metastases. 2002, 5 (1):59-62 Prostate Cancer Prostatic Dis.en
dc.identifier.issn1365-7852-
dc.identifier.pmid15195132-
dc.identifier.doi10.1038/sj.pcan.4500553-
dc.identifier.urihttp://hdl.handle.net/10541/80251-
dc.description.abstractParathyroid hormone-related peptide (PTHrP) is a regulatory protein associated with cell growth in non-osseous tissues and with osteoclast stimulation in bone. It has been implicated in the pathogenesis of bone metastases, particularly in breast carcinoma. PTHrP is widely expressed in primary prostate cancers, but there are few reports of its expression in prostatic metastases. The aim of this study was to examine the expression of PTHrP in bone metastases from patients with untreated adenocarcinoma of the prostate. Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were identified. These were immunohistochemically stained for PTHrP using a murine monoclonal antibody (PTHLP[Ab1]) and the streptavidin-biotin complex technique. Intensity of staining for PTHrP was graded by two observers. In total, PTHrP expression was positive in 5/10 specimens. This was graded as moderate in four and weak in one. In those specimens with positive staining, the expression varied between cells. There was no obvious association between expression of PTHrP and tumour differentiation. PTHrP is expressed in prostatic bone metastases and may have a role in their pathogenesis and pathophysiology. However, expression is not universal.en
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectCancer Proteinsen
dc.subjectProstatic Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshBone Neoplasms-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshMale-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshParathyroid Hormone-Related Protein-
dc.subject.meshProstatic Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleParathyroid hormone-related peptide: expression in prostate cancer bone metastases.en
dc.typeArticleen
dc.contributor.departmentChristie and Hope Hospitals, Manchester, UK. gbryden@hotmail.comen
dc.identifier.journalProstate Cancer and Prostatic Diseasesen

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