E-cadherin and beta-catenin are down-regulated in prostatic bone metastases.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80248
Title:
E-cadherin and beta-catenin are down-regulated in prostatic bone metastases.
Authors:
Bryden, A A G; Hoyland, Judith A; Freemont, Anthony J; Clarke, Noel W ( 0000-0001-7776-8059 ) ; Schembri Wismayer, D; George, Nicholas J
Abstract:
OBJECTIVE: To determine the E-cadherin and beta-catenin expression phenotype in untreated primary prostate cancer and corresponding bone metastases. MATERIALS AND METHODS: Paired bone metastasis and primary prostate specimens were obtained from 14 men with untreated metastatic prostate carcinoma. The tumours were histologically graded by an independent pathologist. Expression of mRNA for E-cadherin and beta-catenin was detected within the tumour cells using in-situ hybridization with a 35S-labelled cDNA probe. The expression of E-cadherin and beta-catenin were graded as uniform, heterogeneous or negative. RESULTS: The mRNA for E-cadherin was expressed in 13 of 14 primary carcinomas and 11 bone metastases; beta-catenin was expressed by 13 and nine, respectively. Of the primary tumours, nine expressed E-cadherin and beta-catenin uniformly; in contrast, all metastases had down-regulated E-cadherin and/or beta-catenin. CONCLUSIONS: The down-regulation of E-cadherin and beta-catenin are a feature of the metastatic phenotype, which may be a significant factor in the genesis of bone metastases. However, this does not appear to be reflected in the expression of these molecules in the primary tumours.
Affiliation:
Christie and Hope Hospital, University of Manchester, UK.
Citation:
E-cadherin and beta-catenin are down-regulated in prostatic bone metastases. 2002, 89 (4):400-3 BJU Int.
Journal:
BJU International
Issue Date:
Mar-2002
URI:
http://hdl.handle.net/10541/80248
PubMed ID:
11872032
Type:
Article
Language:
en
ISSN:
1464-4096
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBryden, A A G-
dc.contributor.authorHoyland, Judith A-
dc.contributor.authorFreemont, Anthony J-
dc.contributor.authorClarke, Noel W-
dc.contributor.authorSchembri Wismayer, D-
dc.contributor.authorGeorge, Nicholas J-
dc.date.accessioned2009-09-08T10:48:57Z-
dc.date.available2009-09-08T10:48:57Z-
dc.date.issued2002-03-
dc.identifier.citationE-cadherin and beta-catenin are down-regulated in prostatic bone metastases. 2002, 89 (4):400-3 BJU Int.en
dc.identifier.issn1464-4096-
dc.identifier.pmid11872032-
dc.identifier.urihttp://hdl.handle.net/10541/80248-
dc.description.abstractOBJECTIVE: To determine the E-cadherin and beta-catenin expression phenotype in untreated primary prostate cancer and corresponding bone metastases. MATERIALS AND METHODS: Paired bone metastasis and primary prostate specimens were obtained from 14 men with untreated metastatic prostate carcinoma. The tumours were histologically graded by an independent pathologist. Expression of mRNA for E-cadherin and beta-catenin was detected within the tumour cells using in-situ hybridization with a 35S-labelled cDNA probe. The expression of E-cadherin and beta-catenin were graded as uniform, heterogeneous or negative. RESULTS: The mRNA for E-cadherin was expressed in 13 of 14 primary carcinomas and 11 bone metastases; beta-catenin was expressed by 13 and nine, respectively. Of the primary tumours, nine expressed E-cadherin and beta-catenin uniformly; in contrast, all metastases had down-regulated E-cadherin and/or beta-catenin. CONCLUSIONS: The down-regulation of E-cadherin and beta-catenin are a feature of the metastatic phenotype, which may be a significant factor in the genesis of bone metastases. However, this does not appear to be reflected in the expression of these molecules in the primary tumours.en
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectProstatic Canceren
dc.subject.meshBone Neoplasms-
dc.subject.meshCadherins-
dc.subject.meshCytoskeletal Proteins-
dc.subject.meshDown-Regulation-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshProstatic Neoplasms-
dc.subject.meshRNA, Messenger-
dc.subject.meshTrans-Activators-
dc.subject.meshbeta Catenin-
dc.titleE-cadherin and beta-catenin are down-regulated in prostatic bone metastases.en
dc.typeArticleen
dc.contributor.departmentChristie and Hope Hospital, University of Manchester, UK.en
dc.identifier.journalBJU Internationalen

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