Fertility preservation and management of gonadal failure associated with lymphoma therapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80246
Title:
Fertility preservation and management of gonadal failure associated with lymphoma therapy.
Authors:
Howell, Simon J; Shalet, Stephen M
Abstract:
Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, either directly or indirectly, is also a significant cause of gonadal dysfunction, and the potential to recover from damage is clearly related to the radiation dose received. Several methods of preserving gonadal function during potentially sterilizing treatment have been considered. At present, sperm banking remains the only proven method in men, although hormonal manipulation to enhance recovery of spermatogenesis and cryopreservation of testicular germ cells are possibilities for the future. Transposition of the ovaries to allow better shielding during radiotherapy is of use in some women, and the prospect of cryopreservation and reimplanation of ovarian tissue appears to be promising.
Affiliation:
Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. Mmassey@picr.man.ac.uk
Citation:
Fertility preservation and management of gonadal failure associated with lymphoma therapy. 2002, 4 (5):443-52 Curr Oncol Rep
Journal:
Current Oncology Reports
Issue Date:
Sep-2002
URI:
http://hdl.handle.net/10541/80246
PubMed ID:
12162920
Type:
Article
Language:
en
ISSN:
1523-3790
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHowell, Simon J-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-09-08T10:44:46Z-
dc.date.available2009-09-08T10:44:46Z-
dc.date.issued2002-09-
dc.identifier.citationFertility preservation and management of gonadal failure associated with lymphoma therapy. 2002, 4 (5):443-52 Curr Oncol Repen
dc.identifier.issn1523-3790-
dc.identifier.pmid12162920-
dc.identifier.urihttp://hdl.handle.net/10541/80246-
dc.description.abstractTreatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, either directly or indirectly, is also a significant cause of gonadal dysfunction, and the potential to recover from damage is clearly related to the radiation dose received. Several methods of preserving gonadal function during potentially sterilizing treatment have been considered. At present, sperm banking remains the only proven method in men, although hormonal manipulation to enhance recovery of spermatogenesis and cryopreservation of testicular germ cells are possibilities for the future. Transposition of the ovaries to allow better shielding during radiotherapy is of use in some women, and the prospect of cryopreservation and reimplanation of ovarian tissue appears to be promising.en
dc.language.isoenen
dc.subject.meshAntineoplastic Agents-
dc.subject.meshFemale-
dc.subject.meshFertility-
dc.subject.meshGonads-
dc.subject.meshHumans-
dc.subject.meshLymphoma-
dc.subject.meshMale-
dc.subject.meshOvarian Failure, Premature-
dc.subject.meshRadiotherapy-
dc.subject.meshTesticular Diseases-
dc.titleFertility preservation and management of gonadal failure associated with lymphoma therapy.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. Mmassey@picr.man.ac.uken
dc.identifier.journalCurrent Oncology Reportsen

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